Open Close
General Information
Symbol
Dmel\gclNLS
Species
D. melanogaster
Name
FlyBase ID
FBal0327512
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

gcl with deletion of the nuclear localization signal (NLS).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

gclNLS heterozygous females are sterile, as they fail to develop mid/late stage egg chambers and do not lay mature eggs, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

gclNLS has female sterile | dominant phenotype, suppressible | partially by Cul3[+]/Cul3gft2

Phenotype Manifest In
Suppressed by
Statement
Reference

gclNLS has egg chamber phenotype, suppressible | partially by Cul3[+]/Cul3gft2

Additional Comments
Genetic Interactions
Statement
Reference

The failure of gclNLS heterozygous females to develop late stage egg chambers and to lay eggs is partially rescued by additional heterozygosity for Cul3gft2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)