FB2026_02 , released June 18, 2026
Allele: Dmel\gclNLS
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General Information
Symbol
Dmel\gclNLS
Species
D. melanogaster
Name
FlyBase ID
FBal0327512
Feature type
allele
Associated gene
Dmel\gcl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Pae et al., 2017)
Progenitor genotype
Cytology
Description

gcl with deletion of the nuclear localization signal (NLS).

(Pae et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      gclNLS heterozygous females are sterile, as they fail to develop mid/late stage egg chambers and do not lay mature eggs, as compared to controls.

      (Pae et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      gclNLS has female sterile | dominant phenotype, suppressible | partially by Cul3[+]/Cul3gft2

      (Pae et al., 2017)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      gclNLS has egg chamber phenotype, suppressible | partially by Cul3[+]/Cul3gft2

      (Pae et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The failure of gclNLS heterozygous females to develop late stage egg chambers and to lay eggs is partially rescued by additional heterozygosity for Cul3gft2.

      (Pae et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      gclNLS
      (Pae et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)