FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\RELAAD.R89G07
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General Information
Symbol
Hsap\RELAAD.R89G07
Species
H. sapiens
Name
FlyBase ID
FBal0329402
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
P{R89G07-p65.AD}
Also Known As
R89G07
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rubin Laboratory at Janelia Farm, 2017)
Progenitor genotype
Carried in construct
P{R89G07-p65.AD}
Cytology
Description

The GMR89G07 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
GMR89G07
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      larval mushroom body output neuron j2

      Comment: when combined with P{R24E12-GAL4.DBD} (combination referred to as 'SS00860')

      (Truman et al., 2023, Saumweber et al., 2018)
      larval abdominal 1 A10a neuron

      Comment: when combined with P{R22E06-GAL4.DBD} (combination referred to as 'SS00911')

      (Jovanic et al., 2019)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Ctet\TeTxLC[TNT.UAS]) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R22E06 and Hsap\RELAAD.R89G07 in larvae significantly reduces navigation away from higher wind speeds, compared to controls, with no effect on movement speed in the absense of wind stimuli; turn rate and size of turns are similar to controls.

      (Jovanic et al., 2019)

      Inhibition (using Hsap\KCNJ25XUAS.EGFP) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R24E12 and Hsap\RELAAD.R89G07 in third instar larvae significantly impairs short-term associative appetitive olfactory memory following training with fructose, with no effect on innate odor (n-amylacetate) or fructose preference, compared to controls.

      (Saumweber et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.R89G07.T:Zzzz\Zip+
      Hsap\RELAAD.R89G07
      Name Synonyms
      Secondary FlyBase IDs
        References (6)