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General Information
Symbol
Dmel\JMJD5KO
Species
D. melanogaster
Name
FlyBase ID
FBal0335412
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

The JMJD5 ORF was replaced with a knock-in cassette containing a Red Fluorescent Protein (RFP) transgene. Replaced region determined from reported primer sequences.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The endogenous JMJD5 open reading frame has been replaced by a loxP cassette which contains both Disc\RFP3xP3.PC and the kanamycin resistance gene.

Insertion components
TI{TI}JMJD5KO
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

JMJD5KO mutants are viable and fertile and do not display any developmental timing defects. JMJD5KO suppresses the variegated phenotype of the w or Sb locus (weak suppression) in the In(1)wm4 or T(2;3)SbV background, respectively.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

JMJD5[+]/JMJD5KO is a non-enhancer of visible | adult stage phenotype of Scer\GAL4C-765, smo5A.UAS.Tag:FLAG

Suppressor of
NOT Suppressor of
Statement
Reference

JMJD5[+]/JMJD5KO is a non-suppressor of visible | adult stage phenotype of Scer\GAL4ey.200.Exel, TAF1BdsRNA.UAS

JMJD5[+]/JMJD5KO is a non-suppressor of visible | adult stage phenotype of Scer\GAL4C-765, smo5A.UAS.Tag:FLAG

Phenotype Manifest In
NOT Enhancer of
Statement
Reference

JMJD5[+]/JMJD5KO is a non-enhancer of eye phenotype of Scer\GAL4ey.200.Exel, TAF1BdsRNA.UAS

JMJD5[+]/JMJD5KO is a non-enhancer of wing vein phenotype of Scer\GAL4C-765, smo5A.UAS.Tag:FLAG

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

JMJD5[+]/JMJD5KO is a non-suppressor of eye phenotype of Scer\GAL4ey.200.Exel, TAF1BdsRNA.UAS

JMJD5[+]/JMJD5KO is a non-suppressor of wing vein phenotype of Scer\GAL4C-765, smo5A.UAS.Tag:FLAG

Additional Comments
Genetic Interactions
Statement
Reference

JMJD4KO;JMJD5KO as well as JMJD5KO,JMJD7KO or JMJD5KO,Df(3R)HSPBAP1-KO double mutants are viable and fertile and do not display any developmental timing defects.

Combination with a single copy of JMJD5KO does not modify the frequency of eye tissue to antenna-like malformed structures transformation in adult flies expressing TAF1BdsRNA.Scer\UAS under the control of Scer\GAL4ey.200.Exel nor the disrupted wing vein phenotype of flies expressing smo5A.Scer\UAS.T:Zzzz\FLAG driven by Scer\GAL4C-765 but it partially suppresses the massive eye overgrowth in flies expressing ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 with Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)