FB2026_02 , released June 18, 2026
Allele: Dmel\CG80461
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General Information
Symbol
Dmel\CG80461
Species
D. melanogaster
Name
FlyBase ID
FBal0336467
Feature type
allele
Associated gene
Dmel\CG8046
Associated Insertion(s)
TI{TI}CG80461
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Paik et al., 2017)
Mutagen
CRISPR/Cas9
(Paik et al., 2017)
Progenitor genotype
Associated Insertion(s)
TI{TI}CG80461
Cytology
Description

Deletion of the entire (~1.3kb) coding region of CG8046 and replacement with a 'DsRed' marker.

(Paik et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The survival rate of CG80461 mutants upon systemic Escherichia coli infection is comparable to controls.

      (Paik et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      CG80461 is an enhancer of abnormal immune response | adult stage phenotype of PGRP-LCΔE

      (Paik et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced survival rate upon systemic infection with Escherichia coli observed in PGRP-LCΔE mutants is substantially decreased further in CG80461;PGRP-LCΔE double mutants.

      (Paik et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CG80461
      (Paik et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)