FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cnk116C
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General Information
Symbol
Dmel\cnk116C
Species
D. melanogaster
Name
FlyBase ID
FBal0336632
Feature type
allele
Associated gene
Dmel\cnk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wolfstetter et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement: W806term.

(Wolfstetter et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,416,830..17,416,830 [-]
Nucleotide change:

G17416830A

Amino acid change:

W806term | cnk-PA; W806term | cnk-PB

Reported amino acid change:

W806term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wolfstetter et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cnk116C/Df(2R)BSC161 embryos derived from mothers bearing cnk116C mutant germline clones and thus lacking both maternal and zygotic cnk show a complete loss of muscle founder cells at stage 11/12.

      (Wolfstetter et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      cnk116C is rescued by cnkfTRG01248.sfGFP-TVPTBF

      (Wolfstetter et al., 2017)
      Comments

      The lethality of cnk116C mutants is rescued by combination with cnkfTRG1248.

      (Wolfstetter et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cnk116C
      (Wolfstetter et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)