FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AdamTS-AE591A.UAS
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General Information
Symbol
Dmel\AdamTS-AE591A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0336694
Feature type
allele
Associated gene
Dmel\AdamTS-A
Associated Insertion(s)
Carried in Construct
P{UAS-AdamTS-A.E591A}
Key Links
Transgenic product class
missense_variant
(Skeath et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Skeath et al., 2017)
Mutagen
in vitro construct
(Skeath et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-AdamTS-A.E591A}
Cytology
Description

UAS regulatory sequences drive expression of a protease-dead version (contains the amino acid replacement E591A) of the AdamTS-A-RB isoform (derived from the GH16393 cDNA clone).

(Skeath et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
AdamTS-A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AdamTS-AE591A.UAS under the control of Scer\GAL4elav.PU (combined with Scer\GAL80repo.PL) does not cause any morphological defects in larval brain but expression driven by Scer\GAL4repo results in elongated ventral nerve cord.

      (Skeath et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4repo/AdamTS-AE591A.UAS partially rescues AdamTS-Arnwy2/AdamTS-Arnwy1

      (Skeath et al., 2017)
      Comments

      Expression of AdamTS-AE591A.UAS under the control of Scer\GAL4repo partially rescues the neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-Arnwy1/AdamTS-Arnwy2 larval brain: ~45% of larvae exhibit modest invasion phenotype. However, all the larvae show abnormal elongation of the ventral nerve cord.

      (Skeath et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AdamTS-AE591A.Scer\UAS
      AdamTS-AE591A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)