FlyBase Allele Report: Dmel\cbc[HMC06558]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\cbc^HMC06558

General Information

Symbol

Dmel\cbc^HMC06558

Species

D. melanogaster

Name

FlyBase ID

FBal0337027

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC06558}

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC06558}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of pontocerebellar hypoplasia type 10

CEA

(Schmidt et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C57

(Schmidt et al., 2022)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C164

(Schmidt et al., 2022)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^elav-C155

(Schmidt et al., 2022)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^GMR.PFa

(Schmidt et al., 2022)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^Mef2.PR

(Schmidt et al., 2022)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Schmidt et al., 2022)

lethal - all die during embryonic stage, with Scer\GAL4^C164

(Schmidt et al., 2022)

majority die during P-stage, with Scer\GAL4^C57

(Schmidt et al., 2022)

majority die during P-stage, with Scer\GAL4^C164

(Schmidt et al., 2022)

majority die during P-stage, with Scer\GAL4^elav-C155

(Schmidt et al., 2022)

majority die during P-stage, with Scer\GAL4^Mef2.PR

(Schmidt et al., 2022)

partially lethal - majority die, with Scer\GAL4^C57

(Schmidt et al., 2022)

partially lethal - majority die, with Scer\GAL4^elav-C155

(Schmidt et al., 2022)

partially lethal - majority die, with Scer\GAL4^Mef2.PR

(Schmidt et al., 2022)

partially lethal - majority live, with Scer\GAL4^VGlut1-OK371

(Schmidt et al., 2022)

some die during larval stage, with Scer\GAL4^C164

(Schmidt et al., 2022)

some die during larval stage, with Scer\GAL4^elav-C155

(Schmidt et al., 2022)

some die during larval stage, with Scer\GAL4^VGlut1-OK371

(Schmidt et al., 2022)

some die during P-stage, with Scer\GAL4^VGlut1-OK371

(Schmidt et al., 2022)

viable, with Scer\GAL4^ChAT.7.4

(Schmidt et al., 2022)

viable, with Scer\GAL4^GMR.PFa

(Schmidt et al., 2022)

Phenotype Manifest In

elongation stage spermatid | decreased number, with Scer\GAL4^VP16.bam

(Gallicchio et al., 2024)

Detailed Description

Statement

Reference

The expression of cbc^HMC06558 under the control of Scer\GAL4^elav-C155, Scer\GAL4^C164, Scer\GAL4^VGlut-OK371, Scer\GAL4^C57 or Scer\GAL4^Mef2.PR induces a reduction in third instar larval crawling ability. Conversely, the expression of cbc^HMC06558 under the control of Scer\GAL4^GMR.PFa induces an increase in third instar larval crawling ability.

(Schmidt et al., 2022)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^drm.7.1/cbc^HMC06558 is a suppressor of terminal tracheal cell | larval stage phenotype of Scer\GAL4^drm.7.1, trc^GL01127

(Hudson et al., 2023)

Other

Statement

Reference

Scer\GAL4^drm.7.1, cbc^HMC06558, trc^GL01127 has embryonic/larval dorsal tracheal branch | larval stage phenotype

(Hudson et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

77426

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06558}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cbc^HMC06558

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections