FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lexAGr28b.d.PL
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General Information
Symbol
Ecol\lexAGr28b.d.PL
Species
E. coli
Name
FlyBase ID
FBal0337166
Feature type
allele
Associated gene
Ecol\lexA
Associated Insertion(s)
Carried in Construct
P{Gr28b.d-lexA.L}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Liu et al., 2015)
Progenitor genotype
Carried in construct
P{Gr28b.d-lexA.L}
Cytology
Description

The Gr28b 'd' promoter fragment regulates expression of a lexA::UnkAD driver.

(Liu et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
Gr28b
Encoded product / tool
lexA::UnkAD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      aristal sensory neuron VP2
      (Liu et al., 2015)
      Additional Information
      Statement
      Reference

      EcollexAGr28b.d.PL drives expression in three aristal sensory neuron VP2.

      (Liu et al., 2015)
       
      Marker for
      Reflects expression of
      Gr28b
      (Liu et al., 2015)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Silencing (using ortlexAop.Tag:HA with application of histamine) of Ecol\lexAGr28b.d.PL neurons in adults results in significantly reduced responses of warm projection neurons (PNs) to slow, but not fast, warming, compared to controls; unlike in wild type controls, blocking inhibition (using picrotoxin and CGP54626) in adults with this silencing reduces responses of warm PNs to fast warming and increases responses to cooling. The same manipulation, in the absence of drugs, does not result in any substantial alterations in responses to cooling or warming in warm-cool PNs, compared to controls; unlike in wild type controls, blocking inhibition (using picrotoxin and CGP54626) in adults with this silencing eliminates responses of warm-cool PNs to warming, but not cooling.

      (Liu et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ecol\lexAGr28b.d.PL
      Name Synonyms
      Secondary FlyBase IDs
        References (1)