FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fbxl4Δ45
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General Information
Symbol
Dmel\Fbxl4Δ45
Species
D. melanogaster
Name
FlyBase ID
FBal0337206
Feature type
allele
Associated gene
Dmel\Fbxl4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Li et al., 2017)
Progenitor genotype
PBac{RB}Fbxl4e02322
(Li et al., 2017)
PBac{WH}Fbxl4f04022
(Li et al., 2017)
Cytology
Description

Deletion that removes most of the Fbxl4 transcription unit (generated by recombination between PBac{RB}Fbxl4e02322 and PBac{WH}Fbxl4f04022).

(Li et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:14,235,175..14,237,906 [-]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Li et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fbxl4Δ45 adults exhibit a significant increase in sleep duration during day time (females and males; ZT1-12) and night time (females only; ZT13-24) and a significant decrease in sleep latency period (females only), as compared to controls.

      Fbxl4Δ45 adults moved to constant darkness conditions after 3 days of Light-Darkness entrainment do not exhibit significant differences in circadian period length and activity rhythm strength, as compared to controls.

      The arousal-promoting large ventral lateral neurons (lLNvs) of Fbxl4Δ45 adults exhibit a significant decrease in action potential firing rate and a significant increase in GABA-receptor-mediated current, but not in resting membrane potential or spike amplitude, at both day and night time (ZT1-ZT3 and ZT13-ZT15, respectively), as compared to controls.

      (Li et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Fbxl4Δ45 has abnormal sleep | adult stage phenotype, suppressible by wakeEY02219/wakeEY02219

      (Li et al., 2017)
      Suppressor of
      Statement
      Reference

      Fbxl4Δ45/Fbxl4Δ45 is a suppressor of abnormal sleep | adult stage phenotype of RdlGD4609, Scer\GAL4P2.4.Pdf

      (Li et al., 2017)

      Fbxl4Δ45/Fbxl4Δ45 is a suppressor of abnormal sleep | adult stage phenotype of wakeEY02219

      (Li et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wakeEY02219, Fbxl4Δ45 double homozygotes do not exhibit the sleep defects exhibited by either of the single homozygotes.

      (Li et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fbxl4Δ45
      fbxl4Δ45
      (Li et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)