FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GαqV303D.UAS
Open Close
General Information
Symbol
Dmel\GαqV303D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0337859
Feature type
allele
Associated gene
Dmel\Gαq
Associated Insertion(s)
Carried in Construct
P{UAS-Gαq.V303D}
Key Links
Transgenic product class
missense_variant
(Cao et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Cao et al., 2018)
Mutagen
in vitro construct
(Cao et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-Gαq.V303D}
Cytology
Description

UAS regulatory sequences drive expression of a Gαq cDNA that has been mutated to contain the amino acid replacement V303D.

(Cao et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gαq
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      GαqV303D.UAS/Scer\GAL4GMR.long fails to rescue GαqV303D

      (Cao et al., 2018)
      Comments

      Scer\GAL4GMR.long-driven expression of GαqV303D.Scer\UAS cannot rescue the loss of response to light stimulation (flat electroretinogram response) or the rapid light-dependent retinal degeneration characteristic for GαqV303D adult flies.

      (Cao et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GαqV303D.Scer\UAS
      GαqV303D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)