FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sxcK872M
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General Information
Symbol
Dmel\sxcK872M
Species
D. melanogaster
Name
FlyBase ID
FBal0340183
Feature type
allele
Associated gene
Dmel\sxc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Mariappa et al., 2018)
gene targeting by homologous recombination
(Mariappa et al., 2018)
Progenitor genotype
Cytology
Description

Amino acid replacement: K872M.

(Mariappa et al., 2018)

Catalytically dead version of sxc caused by K872M amino acid replacement; also includes silent mutations in adjacent codons.

(Mariappa et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2R:5,327,665..5,327,667 [+]
Nucleotide change:

AAA5327665ATG

Reported nucleotide change:

AAA?ATG

Amino acid change:

K872M | sxc-PA; K872M | sxc-PB; K872M | sxc-PC

Reported amino acid change:

K872M

Comment:

Two bases of codon 872 are changed in the mutant (AAA to ATG) resulting in a K872M amino acid change. There are also six silent substitutions with in the next six codons. The sequence change in the region of codons 872 to 578 is AAAATCGATCCACAAACCCTC to ATGATCGACCCGCAGACGTTG.

(Mariappa et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      sxcK872M has decreased size | larval stage phenotype, non-enhanceable by OgaKO

      (Czajewski et al., 2024)
      NOT suppressed by
      Statement
      Reference

      sxcK872M has decreased size | larval stage phenotype, non-suppressible by OgaKO

      (Czajewski et al., 2024)
      Phenotype Manifest In
      NOT Enhanced by
      NOT suppressed by
      Statement
      Reference

      sxcK872M has embryonic/larval neuromuscular junction | larval stage phenotype, non-suppressible by OgaKO

      (Czajewski et al., 2024)

      sxcK872M has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by OgaKO

      (Czajewski et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      sxcK872M is partially rescued by sxcUAS.cMa/Scer\GAL4elav.PLu

      (Czajewski et al., 2024)
      Not rescued by

      sxcK872M is not rescued by Scer\GAL4Mhc.PK/sxcUAS.cMa

      (Czajewski et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      OGTK872M
      (Sung et al., 2023)
      sxcK872M
      (Czajewski et al., 2024, Mariappa et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)