FlyBase Allele Report: Dmel\Oga[KO]

General Information

Symbol

Dmel\Oga^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0361594

Feature type

allele

Associated gene

Dmel\Oga

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Muha et al., 2020)

gene targeting by homologous recombination

(Muha et al., 2020)

Progenitor genotype

Cytology

Description

2bp deletion in Oga, resulting in a frameshift and a premature stop codon.

(Muha et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:21,219,675..21,219,676 [+]

Comment:

A 2bp deletion in the second coding exon of Oga causes a frameshift and leads to early translation termination.

(Muha et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates non-syndromic X-linked intellectual disability 106

modeled by sxc^C941Y

(Czajewski et al., 2024)

modeled by sxc^H537A

(Fenckova et al., 2022)

modeled by sxc^H596F

(Fenckova et al., 2022)

modeled by sxc^L283F

(Fenckova et al., 2022)

modeled by sxc^R313P

(Fenckova et al., 2022)

modeled by sxc^A348T

(Fenckova et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | adult stage | light conditional | recessive

(Fenckova et al., 2022)

abnormal sleep | adult stage

(Czajewski et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Oga^KO is an enhancer of visible | adult stage phenotype of sxc^C941Y

(Czajewski et al., 2024)

NOT Enhancer of

Statement

Reference

Oga^KO is a non-enhancer of decreased size | larval stage phenotype of sxc^K872M

(Czajewski et al., 2024)

Suppressor of

Statement

Reference

Oga^KO is a suppressor | partially of decreased size | larval stage phenotype of sxc^C941Y

(Czajewski et al., 2024)

Oga^KO is a suppressor of decreased sleep | adult stage phenotype of sxc^C941Y

(Czajewski et al., 2024)

Oga^KO is a suppressor | partially of abnormal sleep | adult stage phenotype of sxc^C941Y

(Czajewski et al., 2024)

Oga^KO/Oga^KO is a suppressor of abnormal learning | recessive | adult stage | light conditional phenotype of sxc^A348T

(Fenckova et al., 2022)

Oga^KO/Oga[+] is a suppressor of abnormal learning | dominant | adult stage | light conditional phenotype of sxc^H537A

(Fenckova et al., 2022)

Oga^KO/Oga[+] is a suppressor of abnormal learning | dominant | adult stage | light conditional phenotype of sxc^R313P

(Fenckova et al., 2022)

NOT Suppressor of

Statement

Reference

Oga^KO is a non-suppressor of decreased size | larval stage phenotype of sxc^K872M

(Czajewski et al., 2024)

Other

Statement

Reference

Oga^KO, sxc^C941Y has decreased rate of movement | adult stage phenotype

(Czajewski et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

Oga^KO is an enhancer of scutellar bristle | increased number phenotype of sxc^C941Y

(Czajewski et al., 2024)

NOT Enhancer of

Statement

Reference

Oga^KO is a non-enhancer of NMJ bouton | larval stage | decreased number phenotype of sxc^C941Y

(Czajewski et al., 2024)

Oga^KO is a non-enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of sxc^K872M

(Czajewski et al., 2024)

Oga^KO is a non-enhancer of NMJ bouton | larval stage | decreased number phenotype of sxc^K872M

(Czajewski et al., 2024)

Suppressor of

Statement

Reference

Oga^KO is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of sxc^C941Y

(Czajewski et al., 2024)

Oga^KO/Oga^KO is a suppressor of muscle cell of A1-7 lateral longitudinal muscle 1 | larval stage phenotype of sxc^H596F

(Fenckova et al., 2022)

Oga^KO/Oga^KO is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of sxc^H596F

(Fenckova et al., 2022)

Oga^KO/Oga^KO is a suppressor of NMJ bouton | increased number | larval stage phenotype of sxc^H596F

(Fenckova et al., 2022)

NOT Suppressor of

Statement

Reference

Oga^KO is a non-suppressor of NMJ bouton | larval stage | decreased number phenotype of sxc^C941Y

(Czajewski et al., 2024)

Oga^KO is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of sxc^K872M

(Czajewski et al., 2024)

Oga^KO is a non-suppressor of NMJ bouton | larval stage | decreased number phenotype of sxc^K872M

(Czajewski et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Oga^KO

(Czajewski et al., 2024, Fenckova et al., 2022, Muha et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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