FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sxcC941Y
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General Information
Symbol
Dmel\sxcC941Y
Species
D. melanogaster
Name
FlyBase ID
FBal0406644
Feature type
allele
Associated gene
Dmel\sxc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Czajewski et al., 2024)
gene targeting by homologous recombination
(Czajewski et al., 2024)
Progenitor genotype
Cytology
Description

Amino acid replacement: C941Y.

(Czajewski et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:5,327,929..5,327,929 [+]
Nucleotide change:

G5327929A

Amino acid change:

C941Y | sxc-PA; C941Y | sxc-PB; C941Y | sxc-PC

Reported amino acid change:

C941Y

Comment:

Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Czajewski et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  non-syndromic X-linked intellectual disability 106
      is ameliorated by OgaKO
      (Czajewski et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      sxcC941Y has visible | adult stage phenotype, enhanceable by OgaKO

      (Czajewski et al., 2024)
      Suppressed by
      Statement
      Reference

      sxcC941Y has decreased size | larval stage phenotype, suppressible | partially by OgaKO

      (Czajewski et al., 2024)

      sxcC941Y has decreased sleep | adult stage phenotype, suppressible by OgaKO

      (Czajewski et al., 2024)

      sxcC941Y has abnormal sleep | adult stage phenotype, suppressible | partially by OgaKO

      (Czajewski et al., 2024)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      sxcC941Y has scutellar bristle | increased number phenotype, enhanceable by OgaKO

      (Czajewski et al., 2024)
      NOT Enhanced by
      Statement
      Reference

      sxcC941Y has NMJ bouton | larval stage | decreased number phenotype, non-enhanceable by OgaKO

      (Czajewski et al., 2024)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      sxcC941Y has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by OgaKO

      (Czajewski et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sxcC941Y
      (Czajewski et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)