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General Information
Symbol
Dmel\Spg7del
Species
D. melanogaster
Name
FlyBase ID
FBal0340205
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

The Spg7 coding sequence has been deleted and replaced with a Disc\RFP3xP3.cUa marker.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The Spg7 coding sequence has been replaced with a Disc\RFP3xP3.cUa marker.

Insertion components
TI{TI}Spg7del
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Spg7del mutants are viable and fertile, with no detectable anatomical or behavioral phenotypes at a young age, but are significantly short lived and 4 weeks old post eclosion show decreased climbing and flying activity and shown high frequency of paralysis upon heat (36[o]C for 6min) and mechanical (bang) shock, as compared to controls; 4 weeks old Spg7del mutant adults also display extensive brain vacuolization, disorganized photoreceptor synaptic terminals accumulate swollen and morphologically abnormal mitochondria, and loss of integrity of the indirect flight muscles that also show defective mitochondria (i.e. swollen, loosely packed mitochondria with disorganized cristae and compromised respiratory chain function at complexes I and II); Spg7del mutant larvae show altered mitochondrial transport of along larval segmental nerves, namely a significant increase in the frequency of retrograde transport and a significant increase in the speed of anterograde transport, as compared to controls. Spg7del mutants do not display alterations in the number of third instar larval neuromuscular junction synaptic boutons, axonal loss in motor neurons in the adult leg, or reduction in the number of photoreceptor neurons in the visual system, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

Spg7del has short lived phenotype, non-enhanceable by Afg3l2[+]/Afg3l2del

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)