FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nulp11
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General Information
Symbol
Dmel\Nulp11
Species
D. melanogaster
Name
FlyBase ID
FBal0340355
Feature type
allele
Associated gene
Dmel\Nulp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Zeng et al., 2018)
Progenitor genotype
Cytology
Description

A 2bp deletion at 1007-1008bp in the third exon (CDS) of Nulp1, resulting in a premature stop codon within the DUF654 domain, producing an abbreviated poly-peptide chain after 336 amino acids.

(Zeng et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:8,111,651..8,111,652 [+]
Comment:

A 2 bp deletion in the third exon of Nulp1 resulting in a frameshift and early translation termination.

(Zeng et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nulp11 homozygotes are semi-lethal, with the 80% of individuals dying during the pupal stage; the escapers exhibit fully penetrant bent femurs.

      (Zeng et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Nulp11 is rescued by Nulp1PA.UAS/Scer\GAL4arm.PU

      (Zeng et al., 2018)
      Comments

      The expression of Nulp1PA.UAS under the control of Scer\GAL4arm.PU almost completely rescues the semi-lethality and the bent femur phenotype observed in Nulp11 homozygotes.

      (Zeng et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nulp11
      dNulp11#
      (Zeng et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)