FB2026_02 , released June 18, 2026
Allele: Dmel\barrE831
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General Information
Symbol
Dmel\barrE831
Species
D. melanogaster
Name
FlyBase ID
FBal0340394
Feature type
allele
Associated gene
Dmel\barr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jacobs, 2018.7.9)
Progenitor genotype
Cytology
Description

Deletion of base pairs 145 and 146 in the first coding exon leads to a frame shift and stop signal 12 codons downstream, resulting in a mutant protein 59 aa long (rather than the wild-type 735 aa).

(Jacobs, 2018.7.9)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      barrE831 homozygous and barrE831/barrL305 transheterozygous embryos show variable muscle pattern defects, which may include: misshaped and disoriented muscles, missing muscles and/or "holes" in the muscle pattern; distorted pharynx musculature; heart cells are occasionally missing or duplicated. These musculature defects are not observed in barrE831/Df(2L)Exel7077 transheterozygotes that also express barrUASp.cOa.EGFP under the control of Scer\GAL4da.PU.

      barrE831 homozygous embryos also show a disturbed central nervous system, as compared to controls.

      (Jacobs, 2018.7.9)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      barrE831
      (Jacobs, 2018.7.9)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)