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General Information
Symbol
Dmel\hob3
Species
D. melanogaster
Name
FlyBase ID
FBal0340794
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C3214194T

Reported nucleotide change:

C?T

Amino acid change:

R1397term | hob-PB; R1397term | hob-PC

Reported amino acid change:

R1397term

Comment:

Position of mutation on genomic sequence inferred by FlyBase curator from the reported nucleic acid and amino acid changes.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R1397term (revision of data in FBrf0239138).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hob2/hob3 transheterozygous salivary glands display numerous enlarged (Rab7-positive) late endosomes and significantly smaller Sp33 secretory granules at the third instar larval stage; these also display impaired insulin secretion (Dilp5) and Sps3 secretion at the onset of puparium formation, as compared to controls; hob2 homozygous clones within mosaic salivary glands display impaired Sps3 secretion at the onset of puparium formation, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)