FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dacΔPRE1
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General Information
Symbol
Dmel\dacΔPRE1
Species
D. melanogaster
Name
FlyBase ID
FBal0343449
Feature type
allele
Associated gene
Dmel\dac
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Ogiyama et al., 2018)
gene targeting by homologous recombination
(Ogiyama et al., 2018)
Progenitor genotype
Cytology
Description

Approximately 1kb deletion that removes a Polycomb response element (PRE) located 70kb 3' to dac.

(Ogiyama et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:16,422,436..16,423,525 [-]
Comment:

A 1090bp region is replaced with 97bp (GCGGACATATGCACACCTGCGATCATAACTTCGTATAATGTATGCTATACGAAGTTATAGAAGAGCACTAGTAAAGATCTCCATGCATAAGGCGCGC). This deletion maps downstream of dac within the large intron of CG5888.

Inserted_sequence:

GCGGACATATGCACACCTGCGATCATAACTTCGTATAATGTATGCTATACGAAGTTATAGAAGAGCACTAGTAAAGATCTCCATGCATAAGGCGCGC

(Ogiyama et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dacΔPRE1 homozygous adult males do not show ectopic sex combs on the prothoracic leg.

      (Ogiyama et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      dacΔPRE1, ph-p410 has visible | male phenotype

      (Ogiyama et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dacΔPRE1, ph-p410 double mutant adult males frequently show an ectopic sex comb on the T2 prothoracic leg segment, which is not observed in dacΔPRE1 single mutants or wild-type controls; the phenotype progresses to almost full penetrance from 21[o]C to 25[o]C.

      (Ogiyama et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dacΔPRE1
      ΔPRE1
      (Ogiyama et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)