FlyBase Allele Report: Rnor\Prkcz[UAS.act]

General Information

Symbol

Rnor\Prkcz^UAS.act

Species

R. norvegicus

Name

FlyBase ID

FBal0343922

Feature type

allele

Associated gene

Rnor\Prkcz

Associated Insertion(s)

Carried in Construct

P{UAS-rPrkcz.act}

Also Known As

UAS-rPKCζ*

Transgenic product class

inframe_deletion

(Eder et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Eder et al., 2005)

Mutagen

in vitro construct

(Eder et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-rPrkcz.act}

Cytology

Description

UASt regulatory sequences drive expression of an activated version of Rnor\Prkcz, which contains a five amino acid deletion in the autoregulatory pseudosubstrate domain (residues 117-121).

(Eder et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Rnor\Prkcz

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Eder et al., 2005)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^GMR.PU

(Mach et al., 2018)

abnormal size | third instar larval stage, with Scer\GAL4^dpp.blk1

(Mach et al., 2018)

viable, with Scer\GAL4^GMR.PU

(Mach et al., 2018)

visible | adult stage, with Scer\GAL4^GMR.PU

(Mach et al., 2018)

Phenotype Manifest In

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^dpp.blk1

(Mach et al., 2018)

eye, with Scer\GAL4^GMR.PU

(Mach et al., 2018)

Detailed Description

Statement

Reference

Expressing Rnor\Prkcz^UAS.act under the control of Scer\GAL4^GMR.PU results in small and rough eyes.

Expressing Rnor\Prkcz^UAS.act under the control of Scer\GAL4^dpp.blk1 leads to tissue overgrowth in the

anterior-posterior compartment boundary of the wing disc in third instar larvae.

(Mach et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Hrb27C[+]/Hrb27C^F2-1

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible | partially by Hrb27C[+]/Hrb27C^F2-1

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Df(2L)BSC108/+

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible | partially by Df(2L)BSC108/+

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^dpp.blk1 has abnormal size | third instar larval stage phenotype, suppressible by Hrb27C^GD6964, Scer\GAL4^dpp.blk1

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sd^JF02514, Scer\GAL4^GMR.PU

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible by sd^JF02514, Scer\GAL4^GMR.PU

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Hrb27C[+]/Hrb27C^J6

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible | partially by Hrb27C[+]/Hrb27C^J6

(Mach et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has eye phenotype, suppressible by sd^JF02514, Scer\GAL4^GMR.PU

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Hrb27C[+]/Hrb27C^J6

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Hrb27C[+]/Hrb27C^F2-1

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Df(2L)BSC108/+

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Hrb27C^GD6964, Scer\GAL4^GMR.PU

(Mach et al., 2018)

Rnor\Prkcz^UAS.act, Scer\GAL4^dpp.blk1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible by Hrb27C^GD6964, Scer\GAL4^dpp.blk1

(Mach et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rnor\Prkcz^UAS.act

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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