FB2026_03 , released September 17, 2026
Allele: Dmel\Xrp1Ex-long
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General Information
Symbol
Dmel\Xrp1Ex-long
Species
D. melanogaster
Name
FlyBase ID
FBal0344644
Feature type
allele
Associated gene
Dmel\Xrp1
Associated Insertion(s)
P+PBac{XP5.WH5}Xrp1Ex-long
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Mallik et al., 2018)

hypomorphic allele - molecular evidence

(Mallik et al., 2018)
Mutagen
FLPase
(Mallik et al., 2018)
Progenitor genotype
PBac{WH}f05721
(Mallik et al., 2018)
P{XP}Xrp1d04790
(Mallik et al., 2018)
Associated Insertion(s)
P+PBac{XP5.WH5}Xrp1Ex-long
Cytology
Description

Deletion that removes two-thirds of Xrp1 (N-terminal end of the gene is deleted). Expression of all transcripts that encode the long protein isoform is expected to be abolished, but the Xrp1-RD transcript (one of the transcripts that encodes the short protein isoform) is not deleted. qPCR shows that some residual transcript can be detected in the mutants (approximately 8% of wild-type levels), presumably corresponding to the Xrp1-RD mRNA.

(Mallik et al., 2018)

Deletion that removes two-thirds of Xrp1 (N-terminal end of the gene is deleted). Expression of all transcripts that encode the long protein isoform is expected to be abolished, but the Xrp1-RD transcript (one of the transcripts that encodes the short protein isoform) is not deleted. qPCR shows that some residual transcript can be detected in the mutants (approximately 8% of wild-type levels), presumably corresponding to the Xrp1-RD mRNA. A hybrid P+PBac{XP5.WH5} element generated by the recombination event between the two progenitors (PBac{WH}f05721 and P{XP}Xrp1d04790) is present at the site of the deletion.

(Mallik et al., 2018)
Allele components
Component
Use(s)
Inserted element
P+PBac{XP5.WH5}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:18,913,799..18,923,764 [+]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Mallik et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 6
      modeled by caz2
      (Mallik et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Xrp1[+]/Xrp1Ex-long is a suppressor of lethal - all die during pupal stage phenotype of caz2

      (Mallik et al., 2018)

      Xrp1[+]/Xrp1Ex-long is a suppressor | partially of lethal - all die during pupal stage phenotype of cazKO

      (Mallik et al., 2018)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Xrp1Ex-long
      (Tsakiri et al., 2026, Mallik et al., 2018)
      Xrp1UAS-short
      (Tsakiri et al., 2026)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)