FlyBase Allele Report: Dmel\sov[del1]

General Information

Symbol

Dmel\sov^del1

Species

D. melanogaster

Name

FlyBase ID

FBal0344868

Feature type

allele

Associated gene

Dmel\sov

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Jankovics et al., 2018)

Mutagen

FLPase

(Jankovics et al., 2018)

Progenitor genotype

PBac{WH}f04480

(Jankovics et al., 2018)

P{XP}sov^d07849

(Jankovics et al., 2018)

Caused by aberration

Df(1)sov^del1

Cytology

Description

Removes the entire coding region of sov.

(Jankovics et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:6,756,569..6,770,707 [+]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions PBac{WH}f04480 and P{XP}sov^d07849 has resulted in the deletion of the genomic sequence between them.

(Jankovics et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | oogenesis (with sov²)

(Jankovics et al., 2018)

abnormal size | adult stage | female (with sov²)

(Jankovics et al., 2018)

decreased cell number | germline clone | oogenesis | progressive

(Jankovics et al., 2018)

decreased cell number | oogenesis (with sov²)

(Jankovics et al., 2018)

decreased cell number | oogenesis | progressive | somatic clone

(Jankovics et al., 2018)

female sterile (with sov²)

(Jankovics et al., 2018)

lethal - all die during third instar larval stage | recessive

(Jankovics et al., 2018)

neoplasia | oogenesis (with sov²)

(Jankovics et al., 2018)

suppressor of variegation | dominant, with In(1)w^m4h

(Jankovics et al., 2018)

Phenotype Manifest In

cystoblast (with sov²)

(Jankovics et al., 2018)

escort cell (with sov²)

(Jankovics et al., 2018)

escort cell | progressive | somatic clone

(Jankovics et al., 2018)

female germline cell | germline clone | oogenesis | progressive

(Jankovics et al., 2018)

female germline stem cell (with sov²)

(Jankovics et al., 2018)

germarium (with sov²)

(Jankovics et al., 2018)

ovary | adult stage (with sov²)

(Jankovics et al., 2018)

Detailed Description

Statement

Reference

sov²/sov^del1 transheterozygous females exhibit rudimentary ovaries; while most germaria show no germ cells, almost all remaining germaria show germ cell tumors, with each cell containing a single spectrosome. Escort cells are decreased in number, are virtual absent from the niche and fail to extend protrusions.

sov^del1 germline clones in the adult germarium niche are less frequent than control clones if induced during adulthood, but not if induced during L1 stage; adult-induced clones are progressively lost. Both sov^del1 escort cell clones and escort cell number per clone are less frequent than control regardless of the clones being induced during L1 stage or during adulthood.

(Jankovics et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

sov^del1 has lethal - all die during third instar larval stage | recessive phenotype, suppressible by Dp(1;3)DC486/+

(Jankovics et al., 2018)

sov^del1 has lethal - all die during third instar larval stage | recessive phenotype, suppressible by Dp(1;3)FF184439/+