FlyBase Allele Report: Dmel\sov[2]

General Information

Symbol

Dmel\sov²

Species

D. melanogaster

Name

FlyBase ID

FBal0004322

Feature type

allele

Associated gene

Dmel\sov

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Benner et al., 2019, Wayne et al., 1995)

Mutagen

ethyl methanesulfonate

(Wayne et al., 1995)

Progenitor genotype

Cytology

Description

Insertion of a T nucleotide at position 13,420 relative to the first transcription start site of sov. This results in a frameshift.

(Benner et al., 2019)

Insertion of a single nucleotide (T) at position X:6769743 (release 6 genome).

(Jankovics, 2019.3.28)

Frameshift mutation generating a premature stop codon after amino acid 3151, resulting in a truncated mutant protein lacking 152 C-terminal amino acids.

(Jankovics et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion

X:6,769,743..6,769,744 [+]

Inserted_sequence:

Comment:

A "T" is inserted at genome postion X:6769742 causing a frameshift.

(Benner et al., 2019, Jankovics, 2019.3.28)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | oogenesis (with Df(1)sov)

(Benner et al., 2019)

abnormal cell number | oogenesis (with sov^EA42)

(Benner et al., 2019)

abnormal cell number | oogenesis (with sov^ML150)

(Benner et al., 2019)

abnormal cell shape | oogenesis (with sov^del1)

(Jankovics et al., 2018)

abnormal size | adult stage | female (with sov^del1)

(Jankovics et al., 2018)

abnormal size | adult stage | female (with sov^ML150)

(Jankovics et al., 2018)

abnormal size | oogenesis (with Df(1)sov)

(Benner et al., 2019)

abnormal size | oogenesis (with sov^ML150)

(Benner et al., 2019)

decreased cell number | oogenesis (with sov^del1)

(Jankovics et al., 2018)

decreased cell number | oogenesis (with sov^ML150)

(Jankovics et al., 2018)

female fertile (with sov^KG00226)

(Benner et al., 2019)

female fertile (with sov^NP6070)

(Benner et al., 2019)

female fertile | germline clone

(Benner et al., 2019)

female sterile

(Wayne et al., 1995)

female sterile (with Df(1)sov)

(Benner et al., 2019)

female sterile (with sov^del1)

(Jankovics et al., 2018)

female sterile (with sov^EA42)

(Benner et al., 2019)

female sterile (with sov^ML150)

(Benner et al., 2019, Jankovics et al., 2018)

female sterile | recessive

(Benner et al., 2019)

increased cell death | oogenesis (with sov^ML150)

(Jankovics et al., 2018)

male fertile

(Wayne et al., 1995)

neoplasia | oogenesis (with Df(1)sov)

(Benner et al., 2019)

neoplasia | oogenesis (with sov^del1)

(Jankovics et al., 2018)

neoplasia | oogenesis (with sov^EA42)

(Benner et al., 2019)

neoplasia | oogenesis (with sov^ML150)

(Benner et al., 2019, Jankovics et al., 2018)

non-suppressor of variegation, with P{hsp26-pt-T}39C-2

(Benner et al., 2019)

non-suppressor of variegation, with P{hsp26-pt-T}39C-12

(Benner et al., 2019)

non-suppressor of variegation, with P{hsp26-pt-T}118E-3

(Benner et al., 2019)

non-suppressor of variegation, with P{hsp26-pt-T}118E-10

(Benner et al., 2019)

non-suppressor of variegation, with P{hsp26-pt-T}Dyrk3^118E-15

(Benner et al., 2019)

partially lethal (with Df(1)sov)

(Benner et al., 2019)

partially lethal (with sov^ML150)

(Benner et al., 2019)

Phenotype Manifest In

cystoblast (with sov^del1)

(Jankovics et al., 2018)

cystoblast (with sov^ML150)

(Jankovics et al., 2018)

egg chamber

(Hinson et al., 1999)

egg chamber (with Df(1)sov)

(Benner et al., 2019)

egg chamber (with sov^EA42)

(Benner et al., 2019)

escort cell (with sov^del1)

(Jankovics et al., 2018)

escort cell (with sov^ML150)

(Jankovics et al., 2018)

female germline stem cell (with sov^del1)

(Jankovics et al., 2018)

female germline stem cell (with sov^ML150)

(Jankovics et al., 2018)

germarium (with sov^del1)

(Jankovics et al., 2018)

germarium (with sov^ML150)

(Jankovics et al., 2018)

germline cyst

(Wayne et al., 1995)

ovariole

(Hinson et al., 1999, Wayne et al., 1995)

ovariole (with Df(1)sov)

(Benner et al., 2019)

ovariole (with sov^EA42)

(Benner et al., 2019)

ovary

(Mohler and Carroll, 1984)

ovary (with Df(1)sov)

(Benner et al., 2019)

ovary (with sov^EA42)

(Benner et al., 2019)

ovary | adult stage (with sov^del1)

(Jankovics et al., 2018)

ovary | adult stage (with sov^ML150)

(Jankovics et al., 2018)

spectrosome (with Df(1)sov)

(Benner et al., 2019)

spectrosome (with sov^EA42)

(Benner et al., 2019)

spectrosome (with sov^ML150)

(Benner et al., 2019)

Detailed Description

Statement

Reference

The ovaries of sov²/Df(1)sov, sov²/sov^ML150 or sov²/sov^EA42 transheterozygous females, but not sov²/sov^NP6070 transheterozygous females, show a range of phenotypes, including abnormal numbers of spectrosomes in the germarium, degenerate tissue characterized by small, nub-like ovaries comprising dysmorphic germaria, ovarian tumors and empty ovarioles.

Eggs from sov² germline clones yield viable progeny.

(Benner et al., 2019)

sov²/sov^del1 and sov²/sov^ML150 transheterozygous females exhibit rudimentary ovaries; while most germaria show no germ cells, almost all remaining germaria show germ cell tumors, with each cell containing a single spectrosome. Escort cells are decreased in number and are virtual absent from the niche.

Germaria in sov²/sov^ML150 transheterozygotes also show an increase in apoptotic cells, as compared to controls.

(Jankovics et al., 2018)

Ovarioles and egg chambers are fused. Large nurse-like nuclei are seen.

(Hinson et al., 1999)

Homozygous females produce small ovaries that contain few egg cysts and disorganised ovarioles. The egg cysts that develop have aberrant morphology, including abnormal numbers of nurse cells and patches of necrotic cells. Homozygous females made heterozygous with sov^ML150 or sov^ML185 are viable but the ovarian phenotype becomes more severe.

(Wayne et al., 1995)

Ovaries have abnormally shaped yolks.

(Mohler and Carroll, 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

sov² has female sterile phenotype, suppressible by Dp(1;3)DC486