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Citation
Benner, L., Castro, E.A., Whitworth, C., Venken, K.J.T., Yang, H., Fang, J., Oliver, B., Cook, K.R., Lerit, D.A. (2019). Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary.  Genetics 213(3): 877--895.
FlyBase ID
FBrf0243962
Publication Type
Research paper
Abstract

Heterochromatin-mediated repression is essential for controlling the expression of transposons and for coordinated cell type-specific gene regulation. The small ovary (sov) locus was identified in a screen for female-sterile mutations in Drosophila melanogaster, and mutants show dramatic ovarian morphogenesis defects. We show that the null sov phenotype is lethal and map the locus to the uncharacterized gene CG14438, which encodes a nuclear zinc-finger protein that colocalizes with the essential Heterochromatin Protein 1 (HP1a). We demonstrate Sov functions to repress inappropriate gene expression in the ovary, silence transposons, and suppress position-effect variegation in the eye, suggesting a central role in heterochromatin stabilization.

PubMed ID
PubMed Central ID
PMC6827387 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference