FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pus7fs
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General Information
Symbol
Dmel\Pus7fs
Species
D. melanogaster
Name
FlyBase ID
FBal0345065
Feature type
allele
Associated gene
Dmel\Pus7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(de Brouwer et al., 2018)
Mutagen
CRISPR/Cas9
(de Brouwer et al., 2018)
Progenitor genotype
Cytology
Description

A small deletion of 13 nucleotides in the first half of Pus7 (basepair 600 to 612 in the genome region chr3L:8 ,510,003-8,513,007 (release 6)), which leads to an early frame-shift and a premature stop codon.

(de Brouwer et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:8,510,603..8,510,615 [+]
Comment:

A 13bp deletion in the first third of Pus7 leads to a frameshift and early translation termination.

(de Brouwer et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pus7fs/+, Pus7fs/Pus7fs and Pus7fs/Df(3L)BSC157 adults have significantly increased overall activity, compared to controls; homozygotes and Pus7fs/Df(3L)BSC157 adults have significantly increased angular deviation, resulting in more erratic 15 minute walking paths, compared to controls; Pus7fs/Pus7fs males spend significantly more time engaging in aggressive behavior overall, although no single behavior type is significantly increased, when individually paired with a wild-type control male, compared to these control males; Pus7fs/Pus7fs males tend to win fights against wild-type controls.

      (de Brouwer et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pus7fs
      pus7fs
      (de Brouwer et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)