FlyBase Allele Report: Dmel\Pcl[c421]

General Information

Symbol

Dmel\Pcl^c421

Species

D. melanogaster

Name

FlyBase ID

FBal0345095

Feature type

allele

Associated gene

Dmel\Pcl

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Ma et al., 2018)

Progenitor genotype

Cytology

Description

421bp deletion within Pcl.

(Ma et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:18,137,109..18,137,529 [+]

Comment:

421bp deletion within Pcl. Deletion boundaries mapped from reported border sequences.

(Ma et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived | dominant

(Ma et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pcl^c421 has long lived | dominant phenotype, enhanceable by Su(z)12^c253/Su(z)12[+]

(Ma et al., 2018)

Pcl^c421 has long lived | dominant phenotype, enhanceable by esc^c289/esc[+]

(Ma et al., 2018)

Suppressed by

Statement

Reference

Pcl^c421, Su(z)12^c253/Su(z)12[+] has long lived | dominant phenotype, suppressible | partially by Tpi[+]/Tpi^c511

(Ma et al., 2018)

Pcl^c421, Su(z)12^c253/Su(z)12[+] has abnormal locomotor behavior | dominant | adult stage | progressive phenotype, suppressible | partially by Tpi[+]/Tpi^c511

(Ma et al., 2018)

Pcl^c421, Su(z)12^c253/Su(z)12[+] has long lived | dominant phenotype, suppressible | partially by Pgi^c392/Pgi[+]

(Ma et al., 2018)

Pcl^c421, Su(z)12^c253/Su(z)12[+] has abnormal locomotor behavior | dominant | adult stage | progressive phenotype, suppressible | partially by Pgi^c392/Pgi[+]

(Ma et al., 2018)

Enhancer of

Statement

Reference

Pcl^c421/Pcl[+] is an enhancer of long lived | dominant phenotype of Su(z)12^c253

(Ma et al., 2018)

Other

Statement

Reference

Pcl^c421, Su(z)12^c253/Su(z)12[+] has abnormal locomotor behavior | dominant | adult stage | progressive phenotype

(Ma et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Pcl^c421, Su(z)12^c253 double heterozygotes show a progressive increase in climbing ability, as it only manifests in old/30-days adults and not in young/3-days adults, as compared to age-matched controls.

(Ma et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pcl⁴²¹

(Ma et al., 2018)

Pcl^c421

(Ma et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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