FB2026_02 , released June 18, 2026
Allele: Dmel\Su(z)12c253
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General Information
Symbol
Dmel\Su(z)12c253
Species
D. melanogaster
Name
FlyBase ID
FBal0345096
Feature type
allele
Associated gene
Dmel\Su(z)12
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Ma et al., 2018)
Progenitor genotype
Cytology
Description

253bp deletion within Su(z)12.

(Ma et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:19,921,167..19,921,419 [-]
Comment:

253bp deletion within Su(z)12. Deletion boundaries mapped from reported border sequences.

(Ma et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Su(z)12c253 has long lived | dominant phenotype, enhanceable by Pclc421/Pcl[+]

      (Ma et al., 2018)

      Su(z)12c253 has long lived | dominant phenotype, enhanceable by escc289/esc[+]

      (Ma et al., 2018)
      Suppressed by
      Statement
      Reference

      Pclc421, Su(z)12c253/Su(z)12[+] has long lived | dominant phenotype, suppressible | partially by Tpi[+]/Tpic511

      (Ma et al., 2018)

      Pclc421, Su(z)12c253/Su(z)12[+] has abnormal locomotor behavior | dominant | adult stage | progressive phenotype, suppressible | partially by Tpi[+]/Tpic511

      (Ma et al., 2018)

      Pclc421, Su(z)12c253/Su(z)12[+] has long lived | dominant phenotype, suppressible | partially by Pgic392/Pgi[+]

      (Ma et al., 2018)

      Pclc421, Su(z)12c253/Su(z)12[+] has abnormal locomotor behavior | dominant | adult stage | progressive phenotype, suppressible | partially by Pgic392/Pgi[+]

      (Ma et al., 2018)
      Enhancer of
      Statement
      Reference

      Su(z)12c253/Su(z)12[+] is an enhancer of long lived | dominant phenotype of escc289

      (Ma et al., 2018)

      Su(z)12c253/Su(z)12[+] is an enhancer of long lived | dominant phenotype of Pclc421

      (Ma et al., 2018)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pclc421, Su(z)12c253 double heterozygotes show a progressive increase in climbing ability, as it only manifests in old/30-days adults and not in young/3-days adults, as compared to age-matched controls.

      (Ma et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(z)12253
      (Ma et al., 2018)
      Su(z)12c253
      (Vaziri et al., 2020, Ma et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)