FB2026_02 , released June 18, 2026
Allele: Dmel\tprD1
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General Information
Symbol
Dmel\tprD1
Species
D. melanogaster
Name
FlyBase ID
FBal0345567
Feature type
allele
Associated gene
Dmel\tpr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Drees et al., 2019)
Mutagen
CRISPR/Cas9
(Drees et al., 2019)
Progenitor genotype
Cytology
Description

Frameshift mutation (8bp deletion) in the 5' region of the tpr open reading frame.

(Drees et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:21,800,799..21,800,806 [-]
Comment:

A frameshift mutaiton (8bp deletion) near the beginning of the tpr coding sequence.

(Drees et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tprD1 homozygous stage 17 embryos fail to clear liquid from the trachea. In tprD1 homozygous stage 17 embryos the taenidial folds are detached from the apical side of tracheal cells, although fold formation is not affected, as compared to controls.

      (Drees et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tprD1 is rescued by Scer\GAL4btl.PS/tprUAS.cDa

      (Drees et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tprD1
      (Drees et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)