FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nur2
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General Information
Symbol
Dmel\nur2
Species
D. melanogaster
Name
FlyBase ID
FBal0346063
Feature type
allele
Associated gene
Dmel\nur
Associated Insertion(s)
TI{TI}nur2
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Toda et al., 2019)
Mutagen
CRISPR/Cas9
(Toda et al., 2019)
Progenitor genotype
Associated Insertion(s)
TI{TI}nur2
Cytology
Description

Complete removal of the nur gene, replacing the single nur exon with an attP and a loxP site.

(Toda et al., 2019)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:13,735,995..13,737,224 [+]
Comment:

The nur gene has been completely removed and replaced with an attP site and an eyeless promoter-DsRed flanked by LoxP.

(Toda and Sehgal, 2019.4.9)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Under standard conditions, nur2 homozygotes and nur2/nur3 transheterozygotes do not show consistent effects on sleep. nur2/nur3 transheterozygotes show increased mid-nighttime arousal by light stimuli (i.e. more individuals get aroused by a light pulse and then show higher speed of movements and higher sleep latency than controls) and by odor stimuli (i.e. more individuals get aroused by a concentrated 3-Octanol odor than controls). Following 6h of sleep deprivation during nighttime, transheterozygotes show delayed sleep recovery despite of no changes in overall sleep duration over the following 12h daytime period, as compared to heterozygous controls.

      nur2 homozygotes infected with E. coli or S. marcescens show decreased infection-induced sleep, as compared to infected controls; they also show increased S. marcescens bacteria load, as compared to infected controls.

      (Toda et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nur2
      (Toda et al., 2019)
      nurattp
      (Toda et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)