FB2020_06, released Dec 22, 2020

Gene: Dmel\nur

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General Information
Symbol
Dmel\nur
Species
D. melanogaster
Name
nemuri
Annotation Symbol
CG31813
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051813
Gene Model Status
Current
Stock Availability
2 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

BG:DS08249.4

Key Links
Genomic Location
Cytogenetic map
34D1-34D1
Sequence location
2L:13,736,138..13,737,030 [+]
Recombination map

2-49

RefSeq locus
NT_033779 REGION:13736138..13737030
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in antimicrobial humoral response
inferred from direct assay
(Toda et al., 2019)
involved_in sleep
inferred from mutant phenotype
(Toda et al., 2019)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Toda et al., 2019)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Protein Function (UniProtKB)
    Antimicrobial protein which is essential for the homeostatic regulation of sleep. Promotes sleep following sleep deprivation or bacterial infection and increases survival following bacterial infection. Likely to promote survival to bacterial infection in two ways; by contributing to the innate immune response and by promoting sleep during sickness to aid recovery.
    (UniProt, Q8IP68)
    Gene Model and Products
    Number of Transcripts
    2
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\nur for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Gene model reviewed during 5.52

    Sequence Ontology: Class of Gene
    nuclear_gene
    protein_coding_gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    nur-RA
    FBtr0080531
    NM_165053
    653
    172
    nur-RB
    FBtr0343656
    NM_001298977
    893
    172
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    nur-PA
    FBpp0080108
    19.2
    172
    11.94
    NP_723832
    AAN10843
    nur-PB
    FBpp0310251
    19.2
    172
    11.94
    NP_001285906
    AHN54420
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    172 aa isoforms: nur-PA, nur-PB
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nur using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    located_in extracellular space
    inferred from direct assay
    (Toda et al., 2019)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\nur in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 3 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 4 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of nur
    Transgenic constructs containing regulatory region of nur
    Deletions and Duplications ( 1 )
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    viable, with Scer\GAL4Mef2.PR
    viable, with Scer\GAL4pnr-MD237
    Other Phenotypes
    Allele
    circadian rhythm defective | RU486 conditional, with Scer\GAL4elav.Switch.PO
    immune response defective | adult stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
    locomotor behavior defective | RU486 conditional, with Scer\GAL4elav.Switch.PO
    long lived |  :conditional | RU486 conditional, with Scer\GAL4elav.Switch.PO
    sleep defective, with Scer\GAL4GMR12D05
    sleep defective, with Scer\GAL4GMR12G09
    sleep defective, with Scer\GAL4GMR14H04
    sleep defective, with Scer\GAL4GMR16H04
    sleep defective, with Scer\GAL4GMR17C09
    sleep defective, with Scer\GAL4GMR18C12
    sleep defective, with Scer\GAL4GMR19F06
    sleep defective, with Scer\GAL4GMR19G10
    sleep defective, with Scer\GAL4GMR19H09
    sleep defective, with Scer\GAL4GMR20D06
    sleep defective, with Scer\GAL4GMR25B12
    sleep defective, with Scer\GAL4GMR34G02
    sleep defective, with Scer\GAL4GMR35D04
    sleep defective, with Scer\GAL4GMR37F05
    sleep defective, with Scer\GAL4GMR41E01
    sleep defective, with Scer\GAL4GMR42E12
    sleep defective, with Scer\GAL4GMR52B11
    sleep defective, with Scer\GAL4GMR55C02
    sleep defective, with Scer\GAL4GMR59D08
    sleep defective, with Scer\GAL4GMR64H04
    sleep defective, with Scer\GAL4GMR70E03
    sleep defective, with Scer\GAL4GMR70G01
    sleep defective, with Scer\GAL4GMR70G02
    sleep defective, with Scer\GAL4GMR72B07
    sleep defective, with Scer\GAL4GMR72G06
    sleep defective, with Scer\GAL4GMR75F05
    sleep defective, with Scer\GAL4GMR82G02
    sleep defective, with Scer\GAL4GMR84C10
    sleep defective, with Scer\GAL4GMR88H12
    sleep defective, with Scer\GAL4GMR92E10
    sleep defective, with Scer\GAL4GMR92H01
    sleep defective, with Scer\GAL4GMR93G09
    sleep defective, with Scer\GAL4VT003282
    sleep defective, with Scer\GAL4VT005521
    sleep defective, with Scer\GAL4VT008500
    sleep defective, with Scer\GAL4VT008975
    sleep defective, with Scer\GAL4VT009131
    sleep defective, with Scer\GAL4VT016270
    sleep defective, with Scer\GAL4VT018146
    sleep defective, with Scer\GAL4VT025741
    sleep defective, with Scer\GAL4VT029208
    sleep defective, with Scer\GAL4VT031479
    sleep defective, with Scer\GAL4VT036268
    sleep defective, with Scer\GAL4VT037488
    sleep defective, with Scer\GAL4VT040980
    sleep defective, with Scer\GAL4VT046005
    sleep defective, with Scer\GAL4VT046266
    sleep defective, with Scer\GAL4VT050734
    sleep defective, with Scer\GAL4VT054815
    sleep defective, with Scer\GAL4VT056377
    sleep defective, with Scer\GAL4VT058968
    sleep defective, with Scer\GAL4VT061079
    sleep defective, with Scer\GAL4VT062232
    sleep defective | conditional (with nur2)
    sleep defective | conditional (with nur3)
    sleep defective | recessive | conditional
    sleep defective | RU486 conditional, with Scer\GAL4elav.Switch.PO
    Phenotype manifest in
    Allele
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190KU9 )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Dsuz\DS10_00001704
    Drosophila simulans
    Dsim\GD23916
    Drosophila sechellia
    Dsec\GM15146
    Drosophila erecta
    Dere\GG23872
    Drosophila yakuba
    Dyak\BG:DS08249.4
    Drosophila ananassae
    Dana\GF23017
    Drosophila pseudoobscura pseudoobscura
    Dpse\GA16497
    Drosophila persimilis
    Dper\GL26081
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
    No non-Drosophilid orthologies identified
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map

      2-49

      Cytogenetic map
      34D1-34D1
      Sequence location
      2L:13,736,138..13,737,030 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      34D1-34D1
      Limits computationally determined from genome sequence between P{PZ}kuz03782&P{lacW}kuzk14817 and P{lacW}CG7364k07245
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-49

      (FlyBase, 2016)

      2-44.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (2)
      Genomic Clones (24)
      cDNA Clones (35)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Toda et al., 2019)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: nur CG31813

        (Toda et al., 2019)
        Source for database merge of

        Source for merge of: CG31813 BG:DS08249.4

        (FlyBase, 1996-)

        Source for merge of: CG31813 BcDNA:RE62259

        (FlyBase, 1996-)
        Additional comments

        Source for merge of CG31813 BcDNA:RE62259 was a shared cDNA ( date:030728 ).

        (FlyBase, 1996-)
        Other Comments

        New annotation (CG31813) in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Origin and Etymology
        Discoverer
        Etymology

        Named 'nemuri', the Japanese word for 'sleep', as its overexpression results in a significant increase in sleep relative to controls.

        (Toda et al., 2019)
        Identification
        External Crossreferences and Linkouts ( 26 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Synonyms and Secondary IDs (5)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (23)