FlyBase Allele Report: Dmel\Xrp1[M2-73]

General Information

Symbol

Dmel\Xrp1^M2-73

Species

D. melanogaster

Name

FlyBase ID

FBal0346068

Feature type

allele

Associated gene

Dmel\Xrp1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lee et al., 2016)

Progenitor genotype

Cytology

Description

Amino acid replacement: E?term.

(Lee et al., 2018)

Affects an exon common to both Xrp1 isoforms of the protein and is predicted to truncate the long form after Thr367 and the short form after Thr105, before an AT-hook motif and bZip domain that occur near the C-termini of both isoforms.

(Lee et al., 2018)

Nucleotide substitution: G?T.

(Lee et al., 2018)

A G to T transition in the second exon of the Xrp1 gene (position 3R:18 ,925,491 bp, BDGP Release 6), which predicts a nonsense mutation in the open reading frame.

(Lee et al., 2016)

Nucleotide substitution: G18925491T.

(Lee et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:18,925,491..18,925,491 [+]

Nucleotide change:

G18925491T

Amino acid change:

Reported amino acid change:

E?term

(Lee et al., 2018, Lee et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

RpS3^unspecified, Xrp1^M2-73 has abnormal developmental rate phenotype, enhanceable by RpS12^G97D/RpS12^G97D

(Ji et al., 2019)

NOT Enhanced by

Statement

Reference

RpS17⁴, Xrp1^M2-73 has abnormal developmental rate phenotype, non-enhanceable by RpS12^G97D

(Ji et al., 2019)

NOT suppressed by

Statement

Reference

RpS17⁴, Xrp1^M2-73 has abnormal developmental rate phenotype, non-suppressible by RpS12^G97D

(Ji et al., 2019)

Suppressor of

Statement

Reference

Xrp1^M2-73, RpS12^G97D/RpS12^G97D is a suppressor of abnormal developmental rate phenotype of RpS3^unspecified

(Ji et al., 2019)

Other

Statement

Reference

RpS17⁴, Xrp1^M2-73 has abnormal developmental rate phenotype

(Ji et al., 2019)

RpS3^unspecified, Xrp1^M2-73 has abnormal developmental rate phenotype

(Ji et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81270

w^*; P{neoFRT}82B Xrp1^M2-73

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

M2-73

(Lee et al., 2016)

Xrp1^M2-73

(Brown et al., 2021, Blanco et al., 2020, Ji et al., 2019)

Xrp1^m2-73

(Ji et al., 2021, Lee et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close