FB2026_02 , released June 18, 2026
Allele: Dmel\Ir60b3
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General Information
Symbol
Dmel\Ir60b3
Species
D. melanogaster
Name
FlyBase ID
FBal0346705
Feature type
allele
Associated gene
Dmel\Ir60b
Associated Insertion(s)
TI{TI}Ir60b3
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Sang et al., 2024)
Progenitor genotype
Associated Insertion(s)
TI{TI}Ir60b3
Cytology
Description

Deletion that extends from -44 to +724 relative to the Ir60b transcription start site. A w+mW.hs marker has been inserted in place of the deleted sequence.

(Sang et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:24,515,681..24,516,448 [+]
Comment:

A 768bp deletion that starts -44bp upstream of the Ir60b transcription start site. A w+mW.hs marker has been inserted in place of the deleted sequence.

(Sang et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ir60bKO mutant flies do not show significant changes in the expected avoidance response to food laced with different acids (5% acetic acid, 5% glycolic acid, 10% citric acid, 20% lactic acid, 5% tartaric acid, 2% propionic acid, 2% butyric acid, or 10mM HCl), as compared to controls. GRNs enervating S6 and S10 sensilla do not show changes in the responses (frequency of spikes) to glycolic acid (1%), tartaric acid (1%), citric acid (5%), propionic acid (1%), butyric acid (1%), HCl (10mM), and lactic acid (20%), as compared to controls.

      (Rimal et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Ir60b3 has abnormal behavior | adult stage phenotype, non-enhanceable by PoxnΔM22-B5/Poxn70-28

      (Sang et al., 2024)
      NOT suppressed by
      Statement
      Reference

      Ir60b3 has abnormal behavior | adult stage phenotype, non-suppressible by PoxnΔM22-B5/Poxn70-28

      (Sang et al., 2024)
      Enhancer of
      Statement
      Reference

      Ir60b3 is an enhancer of abnormal behavior | adult stage phenotype of PoxnΔM22-B5/Poxn70-28

      (Sang et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ir60b1
      (Rimal et al., 2019)
      Ir60b3
      (Nhuchhen Pradhan et al., 2025, Pandey et al., 2024, Pradhan et al., 2024, Sang et al., 2024, Dhakal et al., 2021)
      Ir60bKO
      Name Synonyms
      Secondary FlyBase IDs
        References (6)