FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HIPP1ΔDsR
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General Information
Symbol
Dmel\HIPP1ΔDsR
Species
D. melanogaster
Name
FlyBase ID
FBal0346866
Feature type
allele
Associated gene
Dmel\HIPP1
Associated Insertion(s)
TI{TI}HIPP1ΔDsR
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Glenn and Geyer, 2019)
Mutagen
CRISPR/Cas9
(Glenn and Geyer, 2019)
gene targeting by homologous recombination
(Glenn and Geyer, 2019)
Progenitor genotype
Associated Insertion(s)
TI{TI}HIPP1ΔDsR
Cytology
Description

Deletion from position -314 to 3912 relative to the HIPP1 transcription start site. A loxP cassette containing a Disc\RFPDsRed(T1).3xP3.cHa marker has been inserted in place of the deleted sequence.

(Glenn and Geyer, 2019)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:20,809,355..20,813,580 [+]
Comment:

Deletion from position -314 to 3912 relative to the HIPP1 transcription start site. A loxP cassette containing a Disc\RFPDsRed(T1).3xP3.cHa marker has been inserted in place of the deleted sequence.

(Glenn and Geyer, 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      HIPP1Δ37/HIPP1ΔDsR transheterozygosity does not affect egg production.

      HIPP1Δ37/HIPP1ΔDsR ovaries carried all stages of oogenesis with only low levels of apoptosis of mid-stage egg chambers.

      HIPP1Δ37/HIPP1ΔDsR testes show no apparent defects.

      (Glenn and Geyer, 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      HIPP1ΔDsR/HIPP1Δ37 is an enhancer of male semi-fertile | progressive phenotype of su(Hw)e04061/su(Hw)2

      (Glenn and Geyer, 2019)
      NOT Suppressor of
      Statement
      Reference

      HIPP1ΔDsR/HIPP1Δ37 is a non-suppressor of female sterile phenotype of su(Hw)e04061/su(Hw)2

      (Glenn and Geyer, 2019)
      Other
      Statement
      Reference

      HIPP1ΔDsR, su(Hw)[+]/su(Hw)2 has male fertile phenotype

      (Glenn and Geyer, 2019)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying one copy of T(2;3)SbV frequently display a mosaic thoracic bristle phenotype, wherein bristles are both short and long, a phenotype that is unaffected by one copy of HIPP1ΔDsR.

      HIPP1ΔDsR/+, su(Hw)2/+, as well as HIPP1Δ37/HIPP1ΔDsR, su(Hw)2/+, all showed normal oogenesis and egg production. The mid-oogenesis apoptosis observed in su(Hw)2/su(Hw)e04061 transheterozygotes is not suppressed by HIPP1Δ37/HIPP1ΔDsR.

      HIPP1Δ37/+, su(Hw)2/+ males are fertile.

      (Glenn and Geyer, 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HIPP1ΔDsR
      Hipp1ΔDsR
      (Park et al., 2023)
      ΔDsR
      (Glenn and Geyer, 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)