FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Srrko
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General Information
Symbol
Dmel\Srrko
Species
D. melanogaster
Name
sr knock-out
FlyBase ID
FBal0349523
Feature type
allele
Associated gene
Dmel\Srr
Associated Insertion(s)
Carried in Construct
Also Known As
srko
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Dai et al., 2019)
Mutagen
CRISPR/Cas9
(Dai et al., 2019)
Progenitor genotype
Cytology
Description

Deletion of all of the coding region of the Srr-RA transcript and most of the coding region of the Srr-RB transcript ( 3R:9366409..9367626 , FB2018_02).

(Dai et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:9,366,409..9,367,626 [+]
Comment:

Deletion of all of the coding region of the Srr-RA transcript and most of the coding region of the Srr-RB transcript ( 3R:9366409..9367626 , R6).

(Dai et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Srrko mutants show decreased sleep only during night-time, with increased sleep latency and increased light pulse-induced arousal during night-time.

      Srrko/SrrKO-Gal4 mutants show decreased night-time sleep.

      (Dai et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SRko
      (Zheng et al., 2025)
      Srrko
      srko
      (Dai et al., 2019)
      Name Synonyms
      sr knock-out
      Secondary FlyBase IDs
        References (2)