FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rheaK17E
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General Information
Symbol
Dmel\rheaK17E
Species
D. melanogaster
Name
FlyBase ID
FBal0349855
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Camp et al., 2018)
Mutagen
CRISPR/Cas9
(Camp et al., 2018)
gene targeting by homologous recombination
(Camp et al., 2018)
cre recombinase
(Camp et al., 2018)
Progenitor genotype
Cytology
Description

The K17E amino acid substitution has been introduced into the endogenous rhea locus. A single loxP site has also been introduced upstream of the transcription start site, in an area with a low degree of sequence conservation.

(Camp et al., 2018)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,561,530..8,561,530 [+]
Nucleotide change:

A8561530G

Amino acid change:

K17E | rhea-PB; K17E | rhea-PC; K17E | rhea-PD; K17E | rhea-PE; K17E | rhea-PF; K17E | rhea-PG; K17E | rhea-PH; K17E | rhea-PI

Reported amino acid change:

K17E

Comment:

The K17E amino acid substitution has been introduced into the endogenous rhea locus. A single loxP site has also been introduced upstream of the transcription start site, in an area with a low degree of sequence conservation.

(Camp et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      rheaABS2

      (Camp et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rheaK17E
      (Camp et al., 2024, Camp et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)