FlyBase Allele Report: Dmel\rhea[ABS2]

General Information

Symbol

Dmel\rhea^ABS2

Species

D. melanogaster

Name

FlyBase ID

FBal0403002

Feature type

allele

Associated gene

Dmel\rhea

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Camp et al., 2024)

Mutagen

CRISPR/Cas9

(Camp et al., 2024)

gene targeting by homologous recombination

(Camp et al., 2024)

Progenitor genotype

Cytology

Description

Amino acid replacement: K941E.

(Camp et al., 2024)

Amino acid replacement: Q942E.

(Camp et al., 2024)

Six amino acid substitutions have been introduced into the rhea ABS2 domain.

(Camp et al., 2024)

Amino acid replacement: Q949E.

(Camp et al., 2024)

Amino acid replacement: K1510E.

(Camp et al., 2024)

Amino acid replacement: R1520E.

(Camp et al., 2024)

Amino acid replacement: K1532E.

(Camp et al., 2024)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

MNV

3L:8,567,109..8,567,111 [+]

Nucleotide change:

CGT8567109GAG

Reported nucleotide change:

CGT?GAG

Amino acid change:

Reported amino acid change:

R1520E

(Camp et al., 2024)

point_mutation

3L:8,565,372..8,565,372 [+]

Nucleotide change:

A8565372G

Reported nucleotide change:

A?G

Amino acid change:

Reported amino acid change:

K941E

(Camp et al., 2024)

point_mutation

3L:8,565,375..8,565,375 [+]

Nucleotide change:

C8565375G

Reported nucleotide change:

C?G

Amino acid change:

Reported amino acid change:

Q942E

(Camp et al., 2024)

point_mutation

3L:8,565,396..8,565,396 [+]

Nucleotide change:

C8565396G

Reported nucleotide change:

C?G

Amino acid change:

Reported amino acid change:

Q949E

(Camp et al., 2024)

point_mutation

3L:8,567,079..8,567,079 [+]

Nucleotide change:

A8567079G

Reported nucleotide change:

A?G

Amino acid change:

Reported amino acid change:

K1510E

(Camp et al., 2024)

point_mutation

3L:8,567,145..8,567,145 [+]

Nucleotide change:

A8567145G

Reported nucleotide change:

A?G

Amino acid change:

Reported amino acid change:

K1532E

(Camp et al., 2024)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryo | dorsal

(Camp et al., 2024)

embryo | dorsal (with rhea^ABS3)

(Camp et al., 2024)

filamentous actin | embryonic stage

(Camp et al., 2024)

larval somatic muscle | embryonic stage

(Camp et al., 2024)

larval somatic muscle | embryonic stage (with Df(3L)79a)

(Camp et al., 2024)

larval somatic muscle | embryonic stage (with rhea^ABS3)

(Camp et al., 2024)

larval somatic muscle | embryonic stage (with rhea^K17E)

(Camp et al., 2024)

muscle tendon junction | embryonic stage

(Camp et al., 2024)

muscle tendon junction | embryonic stage (with rhea^ABS3)

(Camp et al., 2024)

wing | somatic clone

(Camp et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

rhea^ABS2 has majority die during embryonic stage phenotype, non-enhanceable by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

rhea^ABS2 has lethal - all die before end of first instar larval stage phenotype, non-enhanceable by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

rhea^ABS2 has decreased rate of larval locomotory behavior phenotype, non-enhanceable by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

rhea^ABS3/rhea^ABS2 has lethal - all die before end of P-stage phenotype, non-enhanceable by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

NOT suppressed by

Statement

Reference

rhea^ABS2 has majority die during embryonic stage phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

rhea^ABS2 has lethal - all die before end of first instar larval stage phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

rhea^ABS2 has decreased rate of larval locomotory behavior phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

rhea^ABS3/rhea^ABS2 has lethal - all die before end of P-stage phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Vinc^{UASp.FL.TagRFP}

(Camp et al., 2024)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

rhea^ABS2 is rescued by rhea^{KVK-DDD.Ubi-p63E}

(Camp et al., 2024)

Partially rescued by

rhea^ABS2 is partially rescued by rhea^{R2531G.Ubi-p63E}

(Camp et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

rhea^ABS2

(Camp et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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