FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\picHK-2-3
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General Information
Symbol
Dmel\picHK-2-3
Species
D. melanogaster
Name
FlyBase ID
FBal0351279
Feature type
allele
Associated gene
Dmel\pic
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Ly et al., 2019)
Mutagen
ethyl methanesulfonate
(Ly et al., 2019)
Progenitor genotype
Cytology
Description

G to A mutation at position -12 relative to the splice acceptor site of the first intron of pic (revision of data in FBrf0242621).

(Wang, 2019.9.17)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,052,609..13,052,609 [+]
Nucleotide change:

G13052609A

Reported nucleotide change:

G?A

Comment:

Reported as a point mutation (C to T) at position -12 relative to the splice acceptor site of the first intron. Was sequenced on the complementary strand and is actually a G to A mutation.

(Wang, 2019.9.17)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      picHK-2-3 clonal neuroblasts in the larval brain exhibit signs of quiescence: neuroblasts are Mira-positive; show a significant decrease in cell divisions (DNA replication/EdU staining); and show a primary cellular process, whereas control neuroblasts show a typically rounded morphology

      picHK-2-3 homozygotes exhibit a small brain as well as similar signs of quiescence to picHK-2-3 clones: neuroblasts show a significant decrease in cell divisions (both DNA replication/EdU staining and Mitosis/phospho-H3); are significantly decreased in number; and frequently show a primary cellular process, whereas control neuroblasts show a typically rounded morphology.

      picHK-2-3 individuals on aminoacid-depleted food do not show changes in cell division (DNA replication/EdU staining) on mushroom body neuroblast lineages, as compared to controls.

      (Ly et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ddb1HK-2-3
      (Ly et al., 2019)
      picHK-2-3
      (Wang, 2019.9.17)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)