FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cocoonKO
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General Information
Symbol
Dmel\cocoonKO
Species
D. melanogaster
Name
FlyBase ID
FBal0353117
Feature type
allele
Associated gene
Dmel\cocoon
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lee et al., 2019)
Mutagen
CRISPR/Cas9
(Lee et al., 2019)
Progenitor genotype
Cytology
Description

A two base pair deletion of nucleotides 822 and 823, causing a frameshift that results in a change in amino acids 97-99 and a premature stop code inducing a truncation of amino acids 100-318.

(Lee et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:15,473,288..15,473,289 [-]
Comment:

A 2bp deletion leads to a frameshift and early translation termination.

(Lee et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cocoonKO homozygotes do not show a developmental delay compared to controls.

      (Lee et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cocoonMI02615

      (Lee et al., 2019)
      Rescued by

      cocoonKO is rescued by cocoonGFP

      (Lee et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CRISPR-CG7804
      (Lee et al., 2019)
      cocoonKO
      Name Synonyms
      Secondary FlyBase IDs
        References (1)