FB2026_03 , released September 17, 2026
Allele: Dmel\Fas2UAS.cUa
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General Information
Symbol
Dmel\Fas2UAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0353138
Feature type
allele
Associated gene
Dmel\Fas2
Associated Insertion(s)
Carried in Construct
P{UAS-Fas2.U}
Also Known As
UAS-FasII, UAS-Fas2
Key Links
Transgenic product class
wild_type
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-Fas2.U}
Cytology
Description

UAS regulatory sequences drive expression of Fas2.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Fas2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Fas2UAS.cUa under the control of Scer\GAL4let7C does not alter mushroom body α/β lobe morphology.

      Expression of Fas2UAS.cUa under the control of Scer\GAL4c305a results in α'/β' mushroom body lobe neurons projecting into the α/β lobe.

      (Kucherenko et al., 2012)

      The number of secondary branches on the motor neuron that innervates DLMa is reduced when Fas2UAS.cUa is expressed under the control of the neuronal Scer\GAL4elav-C155 driver. As a result, the pool of secondary branches that can form higher order branches is reduced and the number of contact points between the neuron and the muscle is significantly reduced (from 5 to 4.3). When Fas2UAS.cUa is expressed in muscle, under the control of Scer\GAL4Mhc.PW, there is a reduction in the amount of secondary branches on the motor neuron that innervates DLMa. However, secondary branches are longer and occupy a greater area on the muscle surface than wild-type branches. The lower numbers of secondary branches results in a lower number of contact points between the neuron and the muscle (from 5 to 4.4) and a reduction in overall muscle length.

      (Hebbar and Fernandes, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Statement
      Reference

      Fas2UAS.cUa, eve2xCQ.RC.G4DBD is an enhancer of larval intersegmental nerve phenotype of RdlUAS.cSa, eve2xCQ.RC.G4DBD

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, eve2xCQ.RC.G4DBD is an enhancer of larval abdominal intersegmental nerve phenotype of RdlUAS.cSa, eve2xCQ.RC.G4DBD

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, Scer\GAL4eve.RN2 is an enhancer of larval prothoracic intersegmental nerve phenotype of RdlUAS.cSa, Scer\GAL4eve.RN2

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, eve2xCQ.RC.G4DBD is an enhancer of larval mesothoracic intersegmental nerve phenotype of RdlUAS.cSa, eve2xCQ.RC.G4DBD

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, eve2xCQ.RC.G4DBD is an enhancer of larval metathoracic intersegmental nerve phenotype of RdlUAS.cSa, eve2xCQ.RC.G4DBD

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, eve2xCQ.RC.G4DBD is an enhancer of larval prothoracic intersegmental nerve phenotype of RdlUAS.cSa, eve2xCQ.RC.G4DBD

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, Scer\GAL4eve.RN2 is an enhancer of larval intersegmental nerve phenotype of RdlUAS.cSa, Scer\GAL4eve.RN2

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, Scer\GAL4eve.RN2 is an enhancer of larval abdominal intersegmental nerve phenotype of RdlUAS.cSa, Scer\GAL4eve.RN2

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, Scer\GAL4eve.RN2 is an enhancer of larval mesothoracic intersegmental nerve phenotype of RdlUAS.cSa, Scer\GAL4eve.RN2

      (Sanchez-Soriano and Prokop, 2005)

      Fas2UAS.cUa, Scer\GAL4eve.RN2 is an enhancer of larval metathoracic intersegmental nerve phenotype of RdlUAS.cSa, Scer\GAL4eve.RN2

      (Sanchez-Soriano and Prokop, 2005)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Fas2UAS.cUa under the control of Scer\GAL4mir-210-KO in mir-210KO heterozygous adults results in significantly advanced evening peak circadian locomotor activity under light-dark conditions, compared to controls; this is still the case when Scer\GAL80Pdf.PS, but not Scer\GAL80GMR.PU, is used to restrict expression of Fas2UAS.cUa.

      (Niu et al., 2019)

      Expression of Fas2UAS.cUa fails to suppress the synaptic retraction phenotype seen in the NMJs of third instar larvae when NrgGD82 is expressed under the control of Scer\GAL4elav-C155 and Scer\GAL4VGlut1-OK371.

      (Enneking et al., 2013)

      The hyperfasciculation phenotype seen in the axons of eye photoreceptor cells in ate third instar Sema1aUAS.cYa; Scer\GAL4GMR.PF larvae is enhanced by Fas2UAS.cUa - axons are clustered into relatively few large bundles in the lamina and medulla.

      (Cafferty et al., 2006)

      Expression of Fas2UAS.cUa pre- and post-synaptically, under the control of Scer\GAL4shot-OK307 in a Nrg849 heterozygous background fails to suppresses the Nrg849 giant synapse physiological phenotype.

      (Godenschwege et al., 2006)

      Coexpression of RdlUAS.cSa and Fas2UAS.cUa in the 3 U motorneurons (under the control of eve2xCQ.RC.G4DBD results in the co-arrest of 54% of the intersegmental motor nerves, indicating an enhancement on the ISN phenotype observed in RdlUAS.cSa;eve2xCQ.RC.G4DBD overexpression experiments.

      Coexpression of RdlUAS.cSa and Fas2UAS.cUa in the aCC/RP2 axons (under the control of Scer\GAL4eve.RN2 results in the co-arrest of 97% of the intersegmental motor nerves (ISN), indicating an enhancement on the ISN phenotype observed in RdlUAS.cSa;Scer\GAL4eve.RN2 overexpression experiments (where 70% of ISNs are stalled).

      (Sanchez-Soriano and Prokop, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Fas2UAS.cUa/Scer\GAL4hs.PB rescues Fas2spin

      (Adam et al., 2003)

      Fas2UAS.cUa/Scer\GAL4Fas2-spin rescues Fas2spin

      (Adam et al., 2003)

      Fas2UAS.cUa/Scer\GAL4Kurs21 rescues Fas2spinR5

      (Adam et al., 2003)

      Fas2UAS.cUa/Scer\GAL4elav.PLu rescues Fas2spinR5

      (Adam et al., 2003)
      Partially rescues

      Scer\GAL4Mhc.PW/Fas2UAS.cUa partially rescues Fas2e76

      (Hebbar and Fernandes, 2005)

      Scer\GAL4elav-C155/Fas2UAS.cUa partially rescues Fas2e76

      (Hebbar and Fernandes, 2005)

      Fas2UAS.cUa/Scer\GAL4Feb78 partially rescues Fas2spinR5

      (Adam et al., 2003)
      Fails to rescue

      Fas2UAS.cUa/Scer\GAL4Toll-6-D42 fails to rescue Fas2e76

      (Hebbar and Fernandes, 2005)

      Scer\GAL4Aug21/Fas2UAS.cUa fails to rescue Fas2spinR5

      (Adam et al., 2003)

      Scer\GAL4Feb211/Fas2UAS.cUa fails to rescue Fas2spinR5

      (Adam et al., 2003)
      Comments

      Expression of Fas2UAS.cUa can rescue the DLMa innervation phenotype of Fas2e76 mutants, depending on the driver used. Under the control of Scer\GAL4elav-C155, Fas2UAS.cUa reduces the average number of motor neuron contact points along the DLMa in Fas2e76 mutants from 5.8 to 5.1, while this number is reduced to 4.6 when Fas2UAS.cUa is driven by Scer\GAL4Mhc.PW.

      (Hebbar and Fernandes, 2005)

      Expression of Fas2UAS.cUa under the control of Scer\GAL4hs.PB rescues the genitalia rotation defects seen in Fas2spin males if a single heat shock is given at 7 days of development. If Fas2UAS.cUa is expressed under the control of Scer\GAL4hs.PB using heat shock applied before or after this period, little rescuing activity of the Fas2spin male genitalia rotation defects is seen. The genitalia rotation defects seen in Fas2spinR5 males are fully rescued by expression of Fas2UAS.cUa under the control of Scer\GAL4elav.PLu or Scer\GAL4Kurs21. The genitalia rotation defects seen in Fas2spinR5 males are partially rescued by expression of Fas2UAS.cUa under the control of Scer\GAL4Feb78. The genitalia rotation defects seen in Fas2spinR5 males are not rescued by expression of Fas2UAS.cUa under the control of Scer\GAL4Feb211 or Scer\GAL4Aug21. Expression of Fas2UAS.cUa under the control of Scer\GAL4Feb170 either completely rescues or fails to rescue the genitalia rotation defects seen in Fas2spinR5 males (the Scer\GAL4Feb170 allele shows variegated Scer\GAL4 expression).

      (Adam et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fas2UAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Unknown
      Secondary FlyBase IDs
        References (14)