FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dhpr17-4
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General Information
Symbol
Dmel\Dhpr17-4
Species
D. melanogaster
Name
FlyBase ID
FBal0353330
Feature type
allele
Associated gene
Dmel\Dhpr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Zhou et al., 2019)
Mutagen
CRISPR/Cas9
(Zhou et al., 2019)
Progenitor genotype
Cytology
Description

Contains a small deletion (14bp) that results in premature stop of translation.

(Zhou et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:9,134,821..9,134,834 [+]
Comment:

A 14bp deletion just downstream from the Dhpr ATG causes a frameshift and leads to early translation termination.

Consequences_of_mutation:

frameshift

(Zhou et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dhpr17-4 heterozygotes show high mortality during development.

      Dhpr17-4 homozygosity is near full lethal; although adult escapers are fertile and have normal wing posture, they are short lived, show a progressive decrease in climbing activity, and it is very difficult to maintain a homozygous mutant stock. These escapers show thorax muscles fragmentation and loss, and the affected muscle fragments exhibit swollen mitochondria with less cristae. 35-days old adults exhibit a small but significant decrease in the number of TH-positive neurons across the DM, DL1, DL2 and PM clusters.

      (Zhou et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Dhpr17-4 is rescued by DhprTag:V5

      (Zhou et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dhpr17-4
      (Zhou et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)