FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Bxmut2-miR-263b
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General Information
Symbol
Dmel\Bxmut2-miR-263b
Species
D. melanogaster
Name
FlyBase ID
FBal0355570
Feature type
allele
Associated gene
Dmel\Bx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Nian et al., 2019)
Mutagen
CRISPR/Cas9
(Nian et al., 2019)
Progenitor genotype
Cytology
Description

Mutation in the seed sequence of the two mir-263b binding sites within the 3' UTR of Bx.

(Nian et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
X:18,571,650..18,571,692 [+]
Comment:

A single base substitution (A to G at X:18571692 ) in the seed sequence of one of two mir-263b binding sites within the 3' UTR of Bx. This change is in the context of sa total of seven base substitutions in the vicinity. The net change is that the annotated region (GCTCGAAGCGTGCGGTGCCAAAAGAAATTCAAAGCAGTGCCAA) is replaced with CCCCCAAGCGTGGGGTGCCAAAAGAAATTCAAGACAGTGCCAG.

Inserted_sequence:

CCCCCAAGCGTGGGGTGCCAAAAGAAATTCAAGACAGTGCCAG

(Nian et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bxmut2-miR-263b adults show decreased circadian rhythmicity and circadian power under constant dark, and lack morning anticipation activity under light-dark cycles, as compared to wild-type controls.

      Bxmut2-miR-263b adults show disrupted circadian plasticity of sLNv dorsal projections, as mutants show a lower number of axon terminal branches at ZT2 than controls.

      (Nian et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bx*2
      (Nian et al., 2019)
      Bxmut2-miR-263b
      Name Synonyms
      Secondary FlyBase IDs
        References (1)