FlyBase Allele Report: Dmel\His4r[Δ]

General Information

Symbol

Dmel\His4r^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0359533

Feature type

allele

Associated gene

Dmel\His4r

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Copur et al., 2018)

Mutagen

P-element activity

(Copur et al., 2018)

Progenitor genotype

P{EPgy2}His4r^EY06726

(Copur et al., 2018)

Cytology

Description

Imprecise excision of P{EPgy2}His4r^EY06726 results in a 594bp deletion ( 3R:14625816..14626410 , Release 6) that includes the entire His4r coding region.

(Copur et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:14,625,816..14,626,410 [+]

Comment:

595bp deletion resulting from the imprecise excision of P{EPgy2}His4r^EY06726 that removes the entire His4r coding region. The deletion was reported to map to 3R:14625816..14626410 , Release 6.

(Copur et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Copur et al., 2018)

viable

(Copur et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.H4K16R, His4r^Δ has partially lethal - majority die | female limited phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.H4K16R, His4r^Δ has short lived | female limited phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.H4K16R, His4r^Δ has lethal - all die before end of larval stage | male limited phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.wt, His4r^Δ has fertile phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.wt, His4r^Δ has partially lethal - majority die phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.H4K16Q, His4r^Δ has partially lethal - majority die phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.H4K16Q, His4r^Δ has short lived phenotype

(Copur et al., 2018)

Df(2L)His^C, His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt, His4^HisGU.H4K16A, His4r^Δ has lethal - all die during embryonic stage phenotype

(Copur et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Df(2L)His^C, His4r^Δ double homozygotes rescued by 12x copies of the HisGU gene unit (bearing His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt, His3^HisGU.wt and His4^HisGU.wt) are semi-lethal and adults are fertile and show normal lifespan.

Epidermal Df(2L)His^C clones in His4r^Δ homozygotes that also express variants of the HisGU gene unit (12 copies; bearing His1^HisGU.wt, His2A^HisGU.wt, His2B^HisGU.wt and His3^HisGU.wt with either His4^HisGU.wt, His4^HisGU.H4K16R, His4^HisGU.H4K16Q or His4^HisGU.H4K16A) are able to form normal-looking adult structures with sensory bristles.

(Copur et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

His4r^Δ

(Copur et al., 2018)

ΔHis4r

(Samata et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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