FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atg9B5
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General Information
Symbol
Dmel\Atg9B5
Species
D. melanogaster
Name
FlyBase ID
FBal0360351
Feature type
allele
Associated gene
Dmel\Atg9
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kiss et al., 2020)
Mutagen
CRISPR/Cas9
(Kiss et al., 2020)
Progenitor genotype
Cytology
Description

2464bp deletion that removes almost the entire coding sequence of Atg9.

(Kiss et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:16,294,533..16,296,996 [+]
Comment:

A 2464bp deletion that removes almost the entire coding sequence of Atg9. The deletion is reported to start in codon 5 but the identity of the initial base of the deletion was unspecified.

(Kiss et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In Atg9B5 homozygotes, most eggs are retained instead of being laid, rarely deposited eggs are smaller ("dumpless" phenotype, also seen in Atg9B5 germ-line clones), and cytoplasmic streaming is reduced.

      Atg9B5 homozygous nurse cells are fused and multi nucleated in stage 9+ egg chambers (also seen in Atg9B5 germ-line clones), they exhibit fewer and shorter actin cables in stage 10B egg chambers; and their nuclei persist in stage 14 egg chambers.

      In Atg9B5 primary embryonic neurons, the filopodia number is increased.

      Atg9B5 embryos exhibit midline crossing of ventral nerve cord axons that run in parallel to the midline in controls.

      (Kiss et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Atg9B5 has nurse cell phenotype, enhanceable by ena23/ena[+]

      (Kiss et al., 2020)

      Atg9B5 has nurse cell phenotype, enhanceable by chic[+]/chic221

      (Kiss et al., 2020)

      Atg9B5 has nurse cell phenotype, enhanceable by ena23/chic[+]/ena[+]/chic221

      (Kiss et al., 2020)
      Suppressed by
      Statement
      Reference

      Atg9B5, chic221 has nurse cell phenotype, suppressible by Atg9Tag:HA

      (Kiss et al., 2020)

      Atg9B5, ena23 has nurse cell phenotype, suppressible by Atg9Tag:HA

      (Kiss et al., 2020)
      Other
      Statement
      Reference

      Atg9B5, chic[+]/chic221, ena23/ena[+] has nurse cell ring canal | decreased number phenotype

      (Kiss et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      chic221/+ ena23/+ in Atg9B5background leads to a decrease in the number of ring canals in stage 9+ egg chambers.

      (Kiss et al., 2020)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Atg9B5 is rescued by Atg9Tag:HA

      (Kiss et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Atg9B5
      (Jipa et al., 2021, Jacomin et al., 2020, Kiss et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)