FlyBase Allele Report: Dmel\Syt7[M1]

General Information

Symbol

Dmel\Syt7^M1

Species

D. melanogaster

Name

FlyBase ID

FBal0360507

Feature type

allele

Associated gene

Dmel\Syt7

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Guan et al., 2020)

Mutagen

CRISPR/Cas9

(Guan et al., 2020)

Progenitor genotype

Cytology

Description

1bp deletion within exon 1 of Syt7; this results in a frameshift after amino acid residue seven of the wild-type protein.

(Guan et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

4:305,154..305,154 [-]

Comment:

A 1bp deletion in the first coding exon of Syt7 within codon 8 leads to a frameshift.

(Guan et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage | semidominant

(Guan et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage

(Guan et al., 2020)

t-bar | larval stage

(Guan et al., 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Syt7^M1/Syt7^M1 is an enhancer of increased mortality during development phenotype of Syt1^AD4/Syt1^N13

(Guan et al., 2020)

Syt7^M1/Syt7^M1 is an enhancer of abnormal neurophysiology | larval stage phenotype of Syt1^AD4/Syt1^N13

(Guan et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

Syt7^M1/Syt7^M1 is an enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of Syt1^AD4/Syt1^N13

(Guan et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Syt7^M1

(Guan et al., 2020)

syt7^M1

(Sauvola et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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