FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rcd41
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General Information
Symbol
Dmel\Rcd41
Species
D. melanogaster
Name
FlyBase ID
FBal0361270
Feature type
allele
Associated gene
Dmel\Rcd4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Panda et al., 2020)
Mutagen
CRISPR/Cas9
(Panda et al., 2020)
Progenitor genotype
Cytology
Description

445bp deletion within Rcd4 (NT_033779. 5:g.8382966_8383410del ). The start codon is intact, but codons 4-131 are deleted.

(Panda et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:8,382,966..8,383,410 [+]
Comment:

445bp deletion within Rcd4 removes codons 4-131.

(Panda et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rcd41 femoral chordotonal organs are highly disorganized: ciliary rootlets are rarely observed in ordered pairs, are missing in many of the scolopidia, or do not form junctions with basal bodies; basal bodies are defective or absent; centrobin-positive basal bodies are absent; and the actin bundles are disorganized.

      Rcd41 Johnston's organ scolopidia have a single ciliary axoneme (some with ciliary membrane or structural defects) or no axonemes at all.

      (Panda et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from Rcd41 (in combination with Rcd4UASp.EGFP under the control of Scer\GAL4elav-C155 to rescue coordination) mothers exhibit extensive disorganization of the mitotic apparatus from very early stages of development.

      Expression of Rcd4UASp.EGFP under the control of Scer\GAL4elav-C155 suppresses lethality and incoordination phenotypes while it fails to suppress female sterility phenotype of Rcd41 homozygotes.

      (Panda et al., 2020)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Rcd41 is rescued by Rcd4Ubi-p63E.C.EGFP

      (Panda et al., 2020)
      Partially rescued by

      Rcd41 is partially rescued by Scer\GAL4elav-C155/Rcd4UASp.EGFP

      (Panda et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rcd41
      rcd41
      (Panda et al., 2024, Panda et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)