FlyBase Allele Report: Dmel\scny[D1]

General Information

Symbol

Dmel\scny^D1

Species

D. melanogaster

Name

FlyBase ID

FBal0362201

Feature type

allele

Associated gene

Dmel\scny

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Thevenon et al., 2020)

Progenitor genotype

Cytology

Description

1bp deletion within the exon specific to the scny D isoform, downstream of the ATG codon. The mutation results in a frameshift.

(Thevenon et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:5,769,664..5,769,664 [+]

Comment:

A 1bp deletion in codon 21 of the scny-RD, -RG and -RH isoforms causes a frameshift resulting in a premature stop after 35 out of frame codons.

(Thevenon et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with scny^Δ43)

(Thevenon et al., 2020)

decreased body size | larval stage (with scny^Δ43)

(Thevenon et al., 2020)

decreased body weight | adult stage (with scny^Δ43)

(Thevenon et al., 2020)

decreased cell size | larval stage (with scny^Δ43)

(Thevenon et al., 2020)

decreased size | adult stage (with scny^Δ43)

(Thevenon et al., 2020)

viable (with scny^Δ43)

(Thevenon et al., 2020)

visible | adult stage (with scny^Δ43)

(Thevenon et al., 2020)

Phenotype Manifest In

dorsocentral bristle (with scny^Δ43)

(Thevenon et al., 2020)

larval fat cell (with scny^Δ43)

(Thevenon et al., 2020)

scutellar bristle (with scny^Δ43)

(Thevenon et al., 2020)

wing (with scny^Δ43)

(Thevenon et al., 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dUsp36^D1

(Thevenon et al., 2020)

scny^D1

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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