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FB2025_04
,
released October 2, 2025
dUSP36, Usp36, mule, l(3)02331, ubiquitin-specific protease 36
protein deubiquitinase required in germline, epithelial, and intestinal stem cells - acts to repress differentiation genes - deubiquitylates histone H2B and functions in gene silencing - participates in a conserved pathway of chromatin regulation linking H2B ubiquitylation with H3K4me3 methylation
Please see the JBrowse view of Dmel\scny for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.45
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Interacts with atms/PAF1, but not with CycT (PubMed:19039105). Interacts (via C-terminus) with imd (via N-terminus) (PubMed:19837371).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scny using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: cyclical, peak ZT21-0
Comment: maternally deposited
Expressed cyclically in the adult fat body.
The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.
JBrowse - Visual display of RNA-Seq signals
View Dmel\scny in JBrowse3-15
3-13.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
scny negatively regulates the IMD pathway and suppresses fly immunity through its catalytic activity.
Usp36 encodes a deubiquitinating enzyme homologous to the human USP36 protein.
Usp36 mutant larvae are severely impaired in growth and die during the larval stages. They undergo the first larval moult more slowly than wild-type larvae and only a fraction of them undergo the second larval moult. The delayed first larval moult can be partially rescued by feeding ecdysone to the mutant larvae.
mule encodes a deubiquitinating enzyme.
Area matching Drosophila ESTs AA246386 and AA541060.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Source for merge of: Usp36 l(3)02331
Source for merge of: mule anon-WO0118547.247
FlyBase curator comment: Correspondence with author Buszczak revealed that 'scny' = 'CG5505'.
Source for merge of mule anon-WO0118547.247 was sequence comparison ( date:051113 ).
Source for identity of: mule CG5505
Source for identity of: Usp36 mule
Source for identity of: scny Usp36
Overexpression of a long form of the gene inhibit apoptosis, whereas overexpression of the short form has a proapoptotic effect. The gene is thus named "emperor's thumb" for this ability to regulate both life (thumbs up) and death (thumbs down).
