FlyBase Allele Report: Dmel\scny[GD2319]

General Information

Symbol

Dmel\scny^GD2319

Species

D. melanogaster

Name

FlyBase ID

FBal0208953

Feature type

allele

Associated gene

Dmel\scny

Associated Insertion(s)

Carried in Construct

P{GD2319}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2319}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2319

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression of scny^GD2319 under the control of Scer\GAL4^bbg-C96 does not result in a wing phenotype.

Expression of scny^GD2319 under the control of Scer\GAL4^dpp.PU does not result in a bristle phenotype.

(Zhang et al., 2012)

Adults expressing scny^GD2319 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in late pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 60-70% of the Scer\GAL4^pnr-MD237 expression domain.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2319

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

scny^GD2319, Scer\GAL4^GMR.PFa is an enhancer of visible | adult stage phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

scny^GD2319, Scer\GAL4^GMR.PFa is an enhancer of abnormal eye color phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

NOT Enhancer of

Statement

Reference

scny^GD2319, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

scny^GD2319, Scer\GAL4^GMR.PFa is a non-enhancer of abnormal eye color phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

scny^GD2319, Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

NOT Enhancer of

Statement

Reference

scny^GD2319, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The photoreceptor depigmentation phenotype characteristic for adult flies expressing Dronc^UAS.cSa under the control of Scer\GAL4^GMR.PFa is somewhat enhanced by the co-expression of scny^GD2319, whereas no modification of the depigmentation induced by Dronc^{S130A.UAS.cSa} expression is observed.

(Sinenko, 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v11152

w¹¹¹⁸; P{GD2319}v11152

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2319

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Usp36^GD2319

scny^GD2319

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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