FlyBase Allele Report: Dmel\Sol1[UAS.cKa]

General Information

Symbol

Dmel\Sol1^UAS.cKa

Species

D. melanogaster

Name

UAS construct a of Kiragasi

FlyBase ID

FBal0363472

Feature type

allele

Associated gene

Dmel\Sol1

Associated Insertion(s)

Carried in Construct

PBac{UAS-Sol1.K}

Key Links

Transgenic product class

cDNA

(Kiragasi et al., 2020)

wild_type

(Kiragasi et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Kiragasi et al., 2020)

wild_type

(Kiragasi et al., 2020)

Mutagen

in vitro construct

(Kiragasi et al., 2020)

Progenitor genotype

Carried in construct

PBac{UAS-Sol1.K}

Cytology

Description

UAS regulates expression of a cDNA (IP10972) encoding the entire Sol1 ORF.

(Kiragasi et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Sol1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

(Kiragasi et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

(Kiragasi et al., 2020)

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

(Kiragasi et al., 2020)

Detailed Description

Statement

Reference

Expression of Sol1^UAS.cKa under the control of Scer\GAL4^RapGAP1-OK6 leads to an increase in excitatory postsynaptic current (EPSC) amplitudes and quantal contents.

(Kiragasi et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^RapGAP1-OK6, Sol1^UAS.cKa has abnormal neurophysiology | third instar larval stage phenotype, suppressible by KaiR1D^MB01010

(Kiragasi et al., 2020)

Other

Statement

Reference

KaiR1D^UAS.cKa, Scer\GAL4^nSyb.PU, Sol1^UAS.cKa has abnormal neurophysiology | third instar larval stage phenotype

(Kiragasi et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^RapGAP1-OK6, Sol1^UAS.cKa has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by KaiR1D^MB01010

(Kiragasi et al., 2020)

Scer\GAL4^RapGAP1-OK6, Sol1^UAS.cKa has muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage phenotype, suppressible by KaiR1D^MB01010

(Kiragasi et al., 2020)

Other

Statement

Reference

KaiR1D^UAS.cKa, Scer\GAL4^nSyb.PU, Sol1^UAS.cKa has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Kiragasi et al., 2020)

KaiR1D^UAS.cKa, Scer\GAL4^nSyb.PU, Sol1^UAS.cKa has muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage phenotype

(Kiragasi et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Sol1^UAS.cKa and KaiR1D^UAS.cKa under the control of Scer\GAL4^nSyb.PU leads to an increase in EPSC amplitudes and quantal contents when compared to controls.

(Kiragasi et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^RapGAP1-OK6/Sol1^UAS.cKa rescues Sol1^bk1

(Kiragasi et al., 2020)

Scer\GAL4^Sol1.PK/Sol1^UAS.cKa rescues Sol1^bk1

(Kiragasi et al., 2020)

Fails to rescue

Scer\GAL4^G14/Sol1^UAS.cKa fails to rescue Sol1^bk1

(Kiragasi et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sol1^UAS.cKa

Name Synonyms

UAS construct a of Kiragasi

Secondary FlyBase IDs

References (1)

Report Sections

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