FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Afg3l2del
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General Information
Symbol
Dmel\Afg3l2del
Species
D. melanogaster
Name
FlyBase ID
FBal0365437
Feature type
allele
Associated gene
Dmel\Afg3l2
Associated Insertion(s)
TI{TI}Afg3l2del
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Pareek and Pallanck, 2020)
Mutagen
CRISPR/Cas9
(Pareek and Pallanck, 2020)
Progenitor genotype
Associated Insertion(s)
TI{TI}Afg3l2del
Cytology
Description

The Afg3l2 coding sequence has been replaced with DsRed(Unk) through homology-mediated repair.

(Pareek and Pallanck, 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:17,238,719..17,241,910 [-]
Comment:

The Afg3l2 coding sequence has been replaced with DsRed(Unk) through homology-mediated repair. The position of the deletion endpoints on the reference sequence was determined from the reported primer sequences used to generate the homology arms.

(Pareek and Pallanck, 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Pareek and Pallanck, 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is exacerbated by Spg7del
      (Pareek and Pallanck, 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Afg3l2[+]/Afg3l2del is a non-enhancer of short lived phenotype of Spg7del

      (Pareek and Pallanck, 2020)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AFG3L2del
      (Pareek and Pallanck, 2020)
      Afg3l2del
      Name Synonyms
      Secondary FlyBase IDs
        References (1)