FlyBase Allele Report: Dmel\FoxP[UAS.4xgRNA]

General Information

Symbol

Dmel\FoxP^UAS.4xgRNA

Species

D. melanogaster

Name

FlyBase ID

FBal0365539

Feature type

allele

Associated gene

Dmel\FoxP

Associated Insertion(s)

Carried in Construct

P{UAS-FoxP.4xgRNA}

Also Known As

UAS-t:gRNA(4xFoxP), t:gFoxP

Key Links

Transgenic product class

sgRNA

(Palazzo et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

sgRNA

(Palazzo et al., 2020)

Mutagen

in vitro construct

(Palazzo et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-FoxP.4xgRNA}

Cytology

Description

10xUAS regulatory sequences drive expression of a single polycistronic tRNA-gRNA cassette that encodes 4 sgRNAs, each of which targets a different region of the FoxP gene.

(Palazzo et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

FoxP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^futsch-C380, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR55G08, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Toll-6-D42, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

decreased efficacy of learning | adult stage | RU486 conditional, with Scer\GAL4^GS.nSyb.PB, Spyo\Cas9^UAS.cUa

(Ehweiner et al., 2024)

decreased rate of movement | adult stage, with Scer\GAL4^elav.PU, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

decreased rate of movement | adult stage, with Scer\GAL4^futsch-C380, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

decreased rate of movement | adult stage, with Scer\GAL4^GMR55G08, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

decreased rate of movement | adult stage, with Scer\GAL4^Toll-6-D42, Spyo\Cas9^UAS.cUa

(Palazzo et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

92360

w^*; P{UAS-FoxP.4xgRNA}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

FoxP^UAS.4xgRNA

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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